cholamines. JOEL G. HARDMAN AND STEVEN E. MAYER 29 Antagonism of Monoamine Oxidase Inhibitors against Norepinephrine, Acetyicholine and Potassium in the Isolated Nictitating Membrane of the Cat. T. H. TSAI AND W. W. FLEMING 40 A St.udy of the Potentiation of Tryptamine by Monoamine Oxidase Inhibitors in the Dog. JOHN NELSON EBLE 48 Pharmacology of a Group of Phenylpiperazine Tetrazole Derivativ...

Dinucleoside phosphorochloridite were synthesized from phosphorus trichloride and three nucleoside analogues, 3'-fluoro-2',3'-dideoxythymidine (FLT), 2',3'-dideoxy-5-fluoro-3'-thiacytidine (FTC), and 2',3'-dideoxy-3'-thiacytidine (3TC), in a multistep synthesis. Polymer-bound N-Boc p-acetoxybenzyl 5'-O-2'-deoxythymidine was reacted with dinucleoside phosphorochloridite in the presence of 2,6-lu...

N,N-Substituted amine derivatives were designed by utilizing a bioisosterism strategy. Consequently, twenty-two compounds were synthesized and evaluated for their inhibitory activity against CETP. Structure-activity relationship (SAR) studies indicate that hydrophilic groups at the 2-position of the tetrazole and 3,5-bistrifluoromethyl groups on the benzene ring provide important contributions ...

A study of the effect of the tetrazole moiety, a cis-amide bond surrogate, on the Cu(II) coordinating properties of oligopeptides is reported. Insertion of the tetrazole moiety Psi[CN(4)] into the peptide sequence of [D-Ala(2)]deltorphin I changes considerably the coordination ability of the peptide. Potentiometric and spectroscopic results show that if the tetrazole moiety is in a suitable pos...

In this study, the response is derived, high-energy material 1-(4-nitrophenyl)-1H-Tetrazole (NPHT) with boron nitridenano-cages in different conditions of temperature, density functional theory methods were studied. for this purpose, the material on both sides were geometrically optimized, then the calculation of the thermodynamic parameters were performed on all of them. The amount of ΔH, ΔS a...

The aim of the investigation was to establish the chelating ability of a new proctolin analogue of the sequence Arg-Tyr-LeuPsi[CN(4)]Ala-Thr towards copper(II) ions. The insertion of the tetrazole moiety into the peptide sequence has considerably changed the coordination ability of the ligand. Potentiometric and spectroscopic (UV-Vis, CD, EPR) results indicate that the incorporation of 1,5-disu...

cholamines. JOEL G. HARDMAN AND STEVEN E. MAYER 29 Antagonism of Monoamine Oxidase Inhibitors against Norepinephrine, Acetyicholine and Potassium in the Isolated Nictitating Membrane of the Cat. T. H. TSAI AND W. W. FLEMING 40 A St.udy of the Potentiation of Tryptamine by Monoamine Oxidase Inhibitors in the Dog. JOHN NELSON EBLE 48 Pharmacology of a Group of Phenylpiperazine Tetrazole Derivativ...

cholamines. JOEL G. HARDMAN AND STEVEN E. MAYER 29 Antagonism of Monoamine Oxidase Inhibitors against Norepinephrine, Acetyicholine and Potassium in the Isolated Nictitating Membrane of the Cat. T. H. TSAI AND W. W. FLEMING 40 A St.udy of the Potentiation of Tryptamine by Monoamine Oxidase Inhibitors in the Dog. JOHN NELSON EBLE 48 Pharmacology of a Group of Phenylpiperazine Tetrazole Derivativ...