Background: To our knowledge, there is a hypothesis regardingthe association of vitiligo with other autoimmune disorders.Organ-specific autoantibodies are found more frequently in theserum of vitiligo patients. Recent studies have demonstratedthe role of alterations in serum transforming growth factor-beta(TGF-beta) released from regulatory T cells in the pathogenesisof depigmentation observed ...

Background: TGF-β isoforms play crucial roles in diverse cellular processes. Therefore, targeting and inhibiting TGF-β signaling pathway provides a potential therapeutic opportunity. TGF-β isoforms bind and bring the receptors (TβRII and TβRI) together to form a signaling complex in an ordered manner. Objectives: Herein, an antagonistic variant of TGF-β (AnTβ)...

Introduction: Stroke is the third important reason of death in adults and an important cause of adult disability. Previous studies suggest that TGF-alpha can induce neurogenesis after stroke. Here in, we studied neurogenesis effects of the TGF-alpha on subventricular zone following ischemia-reperfusion. Male wistar rats (250-300 g) were divided into ischemia and treatment groups. After inductio...

Background: Multiple studies have examined the potential of growth factors (GF) to enable mesenchymal stromal cells (MSC) nucleus pulposus (NP) cell-like cell differentiation. Here we screened a wide range GF and combinations for supporting NP Methods: Human MSC were stimulated using 86 different TGF-β1, -2, -3, GDF5, -6, Wnt3a, -5a, -11, Shh. Differentiation potency was assessed by alcian blue...

Peroxiredoxin 1 (PRDX1) participates in tumor cell proliferation, apoptosis, migration, invasion, and the epithelial-to-mesenchymal transition (EMT). This study aimed to investigate effect of PRDX1 on EMT airway epithelial cells stimulated with lipopolysaccharide (LPS) transforming growth factor-beta (TGF-β1). overexpression significantly increased proliferation migration human bronchial (BEAS-...

Cardiac fibrosis is a pathological process associated with the development of heart failure. TGF-? and WNT signaling have been implicated in pathogenesis cardiac fibrosis, however, little known about molecular cross-talk between these two pathways. The aim this study was to examine effect exogenous canonical WNT3a non-canonical WNT5a TGF-?-activated human fibroblasts. We found that induced ?-ca...

transforming growth factor beta (tgf-b) is a mediator released by nearly all cell types. it has suppression activity on the immune system, but exactly how this effect is carried out is not clear. previous experiments showed that igg interacts with or carriers active tgf-b, that could suppresses cytotoxic t-cell responses to an immunogenic tumor in mice. since t cell receptor (tcr) has structura...

You have accessJournal of UrologyBladder & Urethra: Anatomy, Physiology Pharmacology (MP08)1 Sep 2021MP08-13 MICRORNA-29a REGULATES TGF-β1-INDUCED EXPRESSION OF COLLAGEN 1a1 IN HUMAN UROTHELIAL CELLS Zunyi Wang, Jianghui Hou, and Dale Bjorling WangZunyi Wang More articles by this author , HouJianghui Hou BjorlingDale View All Author Informationhttps://doi.org/10.1097/JU.0000000000001981.13About...

To investigate the association between immune-cell-related cytokines and development of chronic hepatitis B (CHB), patients with virus (HBV) infection in immunotolerant (IT) phase (n = 30) or envelope antigen (HBeAg)-positive CHB 250) were enrolled this study. Serological indicators plasma cytokine levels measured at time enrollment. The results showed that there significant differences median ...