abstractbackground and objective: satellite cells are muscle stem cells that enter cycle cells due to myotrauma. among activation and proliferation indices of these cells is increase of myod gene expression. but these are contradiction in response of this gene to resistance exercise in fast and slow fibers. thus, the aim of this study was to evaluate the effect of a single bout of resistance ex...

sphingosine-1-phosphate (s1p) is a bioactive platelet-derived sphingolipid involved in regulation, proliferation, differentiation, hypertrophy and anti-apoptosis of cells and activation of satellite cells. the aim of the present study was to investigate s1p as a growth factor in response to resistance training in male wistar rats. 24 eight-week-old male wistar rats (190–250 gr.) were used in th...

background: the purpose of present study was to investigate whether sphingosine 1-phosphate (s1p) levels and its receptors gene expressions are correlated with myod and myogenin following resistance training. materials and methods: 24 eight-week-old male wistar rats (190-250 gr) were assigned randomly to a control (n = 12) or training (n = 12) group. rats climbed a resistance training ladder wi...

Background: The purpose of present study was to investigate whether Sphingosine 1-phosphate (S1P) levels and its receptors gene expressions are correlated with MyoD and myogenin following resistance training. Materials and Methods: 24 eight-week-old male Wistar rats (190-250 gr) were assigned randomly to a control (N = 12) or training (N = 12) group. Rats climbed a resistance training ladder...

the aim of this study was to investigate the effects of an acute bout of exhaustive resistance exercise on the expression of myogenesis modulators (myostatin (mstn) and myod) in male trained and untrained wistar rats’ fast and slow muscles. thirty rats were assigned to three groups: control (n=6), untrained (n=12) and trained (n=12). resistance exercise (weight lifting up a vertical ladder) was...

Introduction: Although exercise training and herbs consumption have protective effects on many diseases, the mechanism of action of exercise training with different intensities and citrus aurantium (CA) extract consumption on the autophagy-dependent MyoD activation pathway is not yet known. The aim of this study was to investigate the effect of eight weeks of moderate intensity continuous train...

The basic helix-loop-helix (bHLH) transcription factor Myod directly regulates gene expression throughout the program of skeletal muscle differentiation. It is not known how a Myod-driven myogenic program is modulated to achieve muscle fiber-type-specific gene expression. Pbx homeodomain proteins mark promoters of a subset of Myod target genes, including myogenin (Myog); thus, Pbx proteins migh...

MyoD is a muscle-specific transcription factor involved in commitment of cells to myogenesis. MyoD mRNA levels differ between fast and slow muscles, suggesting that MyoD may regulate aspects of fibre type. Here we show that detectable MyoD protein becomes restricted during development to the nuclei of the fastest classes of fibres in fast muscles. myoDm1 mice, in which the myoD gene has been di...

Skeletal muscle comprises a heterogeneous population of fibers with important physiological differences. Fast fibers are glycolytic and fatigue rapidly. Slow fibers utilize oxidative metabolism and are fatigue resistant. Muscle diseases such as sarcopenia and atrophy selectively affect fast fibers, but the molecular mechanisms regulating fiber type-specific gene expression remain incompletely u...

RNA-binding proteins play an important role to post-transcriptionally regulate gene expression. During early development they exhibit temporally and spatially regulated expression pattern. The expression of Xenopus laevis Seb4 gene, also known as RBM24 in other vertebrates, is restricted to the lateral and ventral mesoderm during gastrulation and then localized to the somitic mesoderm, in a sim...