Theophylline is well known for its convulsant and proconvulsant action. Some experimental studies also suggest that theophylline and other methylxanthines may impair the protection of antiepileptic drugs. The interaction of theophylline and the antiepileptic drugs diazepam and sodium valproate was studied in pentylenetetrazole (PTZ) - kindled seizures in rats. Pretreatment with both diazepam 4 ...

The influence of fatty diet and standard diet on the bioavailability and plasma half life of conventional theophylline was studied in the rabbit. It was found that standard diet had significantly reduced the extent of oral bioavailability (AUC0-alpha) of theophylline compared to the fasting state. The fatty diet resulted in a significantly increased extent of oral bioavailability (AUC0-alpha an...

serious toxicity other than some nausea. Continued treatment with intravenous theophylline resulted in compensation of her respiratory difficulties. In its literature, Clinical Assays mentions that 8-chlorotheophylline may interfere. Dimenhydrinate is the 8chlorotheophylline salt of the antihistaminic diphenhydrammne. In addition to the theophylline peak on chromatography, there was another pea...

6 Hendeles L, Weinberger M. Theophylline product and dosing interval selection for chronic asthma. J Allergy Clin Immunol 1985; 76:285-91 7 Weinberger M. Clinical and pharmacokinetic concerns of 24-hour dosing with theophylline. Ann Allergy 1986; 56:2-8 8 Hendeles L, Weinberger M. Selection of slow-release theophylline products. J Allergy Clin Immunol 1986; 78(suppl): 743-51 9 Mangura BT, Mania...

The present study is a part of our physicochemical and pharmacological studies in a group of tricyclic theophylline derivatives. The investigated compounds exhibit different pharmacological profiles in comparison to theophylline and have been tested as potential antidepressant and/or antipsychotic agents. The differences in pharmacological action between theophylline and their tricyclic derivat...

Due to a narrow therapeutic range, measurment of theophylline serum levels is highly recommended in patients with a long-term theophylline therapy. In this regard, since blood sampling is an invasive method, exploring alternative methods using other biological fluids in particular saliva samples are targeted. This study was designed to determine any relationship between serum and saliva levels ...

Abstract Introduction: In this study the role of PGE2 as an important inflammatory mediator in Indomethacine and Theophylline effects on joint diameter and vascular response of chronically inflamed rat knee joint to saphenous nerve stimulation was investigated. Methods: Inflammation was induced by intraarticular injection of 0.2 ml Freund,s Complete Adjuvant (FCA) and 3, 7, 14, 21 days post i...

Organic anion transporter 2 (Oat2 [SLC22A7]) is a multispecific organic anion transporter. Although several substrates of human Oat2 (hOat2) have been elucidated, a possible involvement of hOat2 in drug interaction is less defined. The purpose of this study was to investigate the interaction of theophylline with erythromycin mediated by hOat2 using a Xenopus laevis oocyte expression system. Whe...

Due to a narrow therapeutic range, measurment of theophylline serum levels is highly recommended in patients with a long-term theophylline therapy. In this regard, since blood sampling is an invasive method, exploring alternative methods using other biological fluids in particular saliva samples are targeted. This study was designed to determine any relationship between serum and saliva levels ...

We describe a combined gas-chromatographic mass-spectrometric method for determination of theophylline in whole blood. With use of a probability-based matching approach, the extensive gas-chromatographic interference did not affect mass-spectrometric quantitation of theophylline. Concentrations expected and found were linearly related from 1 to 60 mg/liter; the run-to-run coefficient of variati...