OBJECTIVE To compare the tolerability and efficacy of salbutamol and theophylline in treating wheezy infant. DESIGN This was a prospective parallel group study. SETTING AND SUBJECTS Wheezy infants admitted in paediatric ward of Khulna Medical College Hospital from January 1998 to March 1999. MAIN OUTCOME VARIABLES Palatability of drugs, clinical efficacy of drugs and adverse events during...

A sensor system was developed for the determination of theophylline concentrations based on a theophylline-dependent allosteric ribozyme (Soukup, G. A.; Breaker, R. R. Proc. Natl. Acad. Sci. U.S.A. 1999, 96, 3584) in combination with an RNA substrate which is double-labeled with a fluorophore and a quencher dye. In the presence of theophylline, a hammerhead ribozyme domain is switched into an a...

Twenty two preterm infants were prospectively evaluated to assess the need for dose adjustment when converting enteral and parenteral routes of methylxanthine administration. Serum theophylline concentrations remained unchanged in 18 infants after conversion from intravenous aminophylline to theophylline by mouth with dose reduction, as is currently recommended. Intravenous aminophylline and th...

The solubility data of sodium theophylline salt in the water and aqueous hydroxide systems with molarities 0.00, 0.01, 0.10, 0.20, 0.49, 0.96 mol kg −1 at temperatures ranging from 283.15 to 368.15 K are determined via equilibrium method. experimental results show that increases on increasing temperature same concentration NaOH solution decreases an increase temperature. These correlate well po...

The effects of allopurinol, acyclovir and theophylline on the activity of adenosine deaminase (ADA) were studied in 50 mM sodium phosphate buffer pH 7.5 at 27°C, using a UV– Vis spectrophotometer. Adenosine deaminase is inhibited by these ligands, via different types of inhibition. Allopurinol, as a transition state analog of xanthine oxidase, and acyclovir competitively inhibit the catalytic a...

The effects of allopurinol, acyclovir and theophylline on the activity of adenosine deaminase (ADA) were studied in 50 mM sodium phosphate buffer pH 7.5 at 27°C, using a UV– Vis spectrophotometer. Adenosine deaminase is inhibited by these ligands, via different types of inhibition. Allopurinol, as a transition state analog of xanthine oxidase, and acyclovir competitively inhibit the catalytic a...

background: theophylline may reverse steroid resistance and decrease inflammation in patients with chronic pulmonary disease and sulfur mustard (sm) induced bronchiolitis. this study was designed to assess the effects of low-dose theophylline on improvement of pulmonary function tests (pfts) of sm exposed patients.methods: in this comparative observational study, a group of sm-exposed victims d...

BACKGROUND Synthetic riboswitches have been increasingly used to control and tune gene expression in diverse organisms. Although a set of theophylline-responsive riboswitches have been developed for bacteria, fully functional expression elements mediated by synthetic riboswitches in Bacillus subtilis are rarely used because of the host-dependent compatibility between the promoters and riboswitc...

The intermediary metabolism of theophylline has been the subject of a number of studies, but its fate in the body is still unsettled. Kruger and Schmidt (1) working with dogs reported that the administration of theophylline to dogs is followed by the appearance of 3-methylxanthine in the urine. Myers and Wardell (2) and Buchanan, Christman, and Block (3) showed that ingestion of theophylline in...