A double-blind randomised controlled trial was conducted to study the effects of oral theophylline alone compared with oral theophylline and salbutamol in a sample of asthmatic children. Each treatment was administered at maximum recommended dosage. Children treated with the theophylline and salbutamol combination had higher pulse rates, lower peak flow measurements, and depressed blood theophy...

A comprehensive study of release kinetics a hydrophilic drug from bio-aerogels based on pectin was performed. Pectin aerogels were made by polymer dissolution, gelation (in some cases this step omitted), solvent exchange and drying with supercritical CO2. Theophylline loaded its studied in the simulated gastric fluid during 1 h followed intestinal fluid. concentration, initial solution pH conce...

theophylline tablet. J Clin Pharmacol 1982; 22:196-200 3 Osman MA, Patel RB, Irwin DS, Welling PG. Absorption of theophylline from enteric coated and sustained-release furmulations in fasted and non-fasted subject. Biopharm Drug Disposition 1983; 4:63-72 4 Pedersen S, Moller-Petersen J. Erratic absorption of a slowrelease theophylline sprinkle product. Pediatrics 1984; 74:534-38 5 Jonkman HJC, ...

the effects of allopurinol, acyclovir and theophylline on the activity of adenosine deaminase (ada) were studied in 50 mm sodium phosphate buffer ph 7.5 at 27°c, using a uv– vis spectrophotometer. adenosine deaminase is inhibited by these ligands, via different types of inhibition. allopurinol, as a transition state analog of xanthine oxidase, and acyclovir competitively inhibit the catalytic a...

BACKGROUND INTRODUCTION: Birth Asphyxia (Perinatal Asphyxia) in newborn is a condition caused by the inadequate supply of oxygen before, during, or just after birth. Kidney most damaged organ asphyxiated full-term infants. Theophylline considered to be effective as adenosine antagonist reducing renal injury related birth asphyxia OBJECTIVE: To determine mean serum creatinine and glomerular filt...

Doxofylline, which differs from theophylline in containing the dioxalane group at position 7, has comparable efficacy to theophylline in the treatment of respiratory diseases, but with an improved tolerability profile and a favorable risk-to-benefit ratio. Furthermore, it does not have significant drug-drug interactions as exhibited with theophylline, which make using theophylline more challeng...

The effect of non-selective (theophylline) inhibition of cyclic AMP breakdown on norepinephrine stimulated lipolysis rate was investigated in subcutaneous adipose tissue of obese subjects. In addition, changes in interstitial glucose and lactate concentration were assessed by means of the microdialysis technique. The interaction of endogenous released insulin and theophylline on adipocyte metab...

BACKGROUND While dosing theophylline in asthmatics, we should consider that a lot of medicines, substances, conditions and diseases affect the clearance of theophylline, such as smoking, macrolide antibiotics, barbiturates, oral contraceptives, heart and liver insufficiency, alcohol, calcium-antagonists, pneumonia, viral infections, hypoxemia, etc. AIM The aim of the study is to investigate t...

the effect of theophylline on colony stimulating factor production by the lung tissue was investigated. addition of various concentrations of theophylline to the lung conditioned medium enhanced csf production at 10 µg/ml and at higher concentrations showed an inhibitory effect. determination of the phosphate content of the medium showed a decrease at 1-3 hours of incubation. addition of amp to...

we have investigated the effect of theophylline on the kinetics of the catalytic subunit of protein kinase and related factors in lung tissue. the results show that the point of highest concentration of the c subunit of protein kinase which is active in casein phosphorylation is at 3h of incubation time, but in the presence of 100 ilg/ inl and 10µg/ml theophylline, this is shifted to i.s and 2....