with obstructive airway diseases. It is well known that theophylline has a narrow therapeutic range being a plasma concentration of 10—20 mg/ml and is extensively metabolized in humans. Many articles have been published on the drug interactions of theophylline with other coadministered drugs mediated by cytochrome P450 (CYP) 1A2, which is the major metabolizing enzyme for theophylline. For exam...

It is speculated that measurement of serum theophylline concentration alone, without concomitant caffeine level determination, may lead to a false negative (normal) pneumocardiogram due to possible existence of therapeutic caffeine level resulting from the methylation of theophylline. Treatment of neonatal apnea with theophylline as documented by a normal follow-up pneumocardiogram should be co...

Measurement of serum theophylline concentration is usually recommended before intravenous aminophylline is given to patients taking oral theophylline. Fifty patients with worsening airflow obstruction, all of whom were taking oral theophyllines and who had no contraindication to the use of parenteral aminophylline, were randomly allocated into two groups before treatment was given. The dose of ...

OBJECTIVES To assay theophylline blood levels in a sample of Sri Lankan chronic asthmatics taking oral theophylline, and to evaluate a simple and cost effective ultraviolet spectrophotometric assay for theophylline levels in blood. SETTING Chronic asthmatics taking oral theophylline attending medical clinics at the National Hospital of Sri Lanka (NHSL) were recruited for the study. Blood samp...

In automated cell counting of edetic acid (EDTA-2K) anticoagulated blood, thrombocytopenia is occasionally seen which bears no relation to any underlying disease. In this study a heparin and soluble theophylline mixture was used to measure accurately platelet numbers in patients with such pseudothrombocytopenia. In four normal volunteers, a theophylline concentration of more than 7 mg/ml produc...

BACKGROUND Theophylline was shown to induce contracture development in porcine malignant hyperthermia (MH) susceptible (MHS) skeletal muscles in vitro. The purpose of the current study was to investigate the in vivo effects of theophylline in MHS and MH normal (MHN) swine. METHODS MH-trigger-free general anesthesia was performed in MHS and MHN swine. Theophylline was administered intravenousl...

due to a narrow therapeutic range, measurment of theophylline serum levels is highly recommended in patients with a long-term theophylline therapy. in this regard, since blood sampling is an invasive method, exploring alternative methods using other biological fluids in particular saliva samples are targeted. this study was designed to determine any relationship between serum and saliva levels ...

Theophylline poisoning can result in nausea, vomiting, hypotension, cardiac dysrythmias, and seizures. Mortality may be as high as 50%, and life-threatening events may occur without premonitory symptoms.' Because of this, treatment is indicated when serum theophylline concentrations are very high. Charcoal haemoperfusion is effective in lowering serumconcentrations of theophylline.2 We report a...

Description Theophylline in 5% Dextrose Injection, USP is a sterile, nonpyrogenic solution of Theophylline, Anhydrous, USP in 5% Dextrose Injection. It contains no antimicrobial agents. Theophylline is structurally classified as a methylxanthine. It occurs as a white, odorless, crystalline powder with a bitter taste. Anhydrous theophylline has the chemical name 1H-Purine-2,6-dione,3,7-dihydro-1...

theophylline, (1,3-dimethylxanthine) is widely used as a smooth muscle relaxant, myocardial stimulant and a diuretic agent. the most frequent use of theophylline is in treatment of acute and chronic asthma as a bronchodilator. to determine the effect of theophylline on serum electrolyte and uric acid, 21 asthmatic children (age range 1,5-7 years) with severe acute asthma and 25 patients with ch...