The moment of revelation-maybe even of truthcame at 8 51 on a Tuesday morning in the vast auditorium of the Georgia World Congress Centre in Atlanta. It was the second day of the 40th annual scientific session of the American College ofCardiology and Peter Sleight, professor of cardiovascular medicine at the University of Oxford, with his colleagues Rory Collins and Richard Peto, was reporting ...

The first gene therapy that was used on humans was performed for adenosine deaminase (ADA) deficiency in 1990 [1]. In the early days of gene therapy, it was thought to be a break‐ through in the treatment of a number of human diseases including cancer, cardiovascular disease, genetic disease, and so on. However, two severe adverse events in gene therapy served as triggers for the rethinking of ...

Health care workers (HCWs) who have contact with patients have an increased risk of exposure to vaccinepreventable diseases and of spreading those diseases to vulnerable patients. Maintenance of immunity against vaccine-preventable diseases is an essential part of disease-prevention and infection-control programs [1]. Influenza is the most common vaccine-preventable disease, and nosocomial tran...

Two experiments are reported that investigate the difference in g radient of generalization observed between one-category (non-d iscrim inative) and two-category (discrim inative) training. Extrapolating from the resu lts of a number of animal lear ning studies, it was predicted that the g radient should be steeper under discrim inative training. The ® rst experiment con ® rms this basic predic...

Reinforcement learning is very effec#ive for robot learning. Because it does not need prior knowledge and has higher capability of reactive and adaptive behaviors. In our previous works, we proposed new reinforce learning algorithm: "Q-learning with Dynamic Structuring of Exploration Space Based on Genetic Algorithm (QDSEGA)". It is designed for complicated systems with large action-state space...

Background: The increasing use of nuclear radia on for human welfare necessitates the search for new, safe, cost effec ve radio protectors not only for the personnel’s charged with the responsibility of working or tes ng with radia ons in laboratories, but also for general public. With this view the present study has been undertaken to determine the deleterious effects of sub lethal gamma radia...

isk factors for type 2 diabetes and cardiovascular disease CVD) often cluster, including obesity (particularly central), nsulin resistance, hyperglycemia, dyslipoproteinemia, and ypertension. These conditions can also occur in isolation, nd they are exaggerated by physical inactivity and smoking. ince each of these factors increases risk of CVD, the oncept of global cardiometabolic risk (CMR) (...

CD3* peripheral blood T lymphocytes were evaluated for expression of vascular endothelial growth factor (VEGF), an endothelial cell mitogen and potent angiogenic factor. VEGF mRNA expression was confirmed in CD3+ cells and Jurkat cells, a human T-cell line, by reverse transcriptionPCR and in ( ÕU and CDS' T cell subtypes by Northern blot hybridiza tion. Steady-state levels of VEGF mRNA were in...

Ab ac : Ind 4. deno e he eme gence of ma fac o ie i h a ong foc on comm nica ion be een h man , machine and p od c , hich i ppo ed b c be -ph ical em [HPO15]. Among ch em a e a gmen ed eali applica ion , hich ha e g ea al e fo he a embl , moni o ing and main enance of machine . Ye , o da e he e a e no con enien mean fo ende o c ea e a gmen ed eali con en in a imple manne .We in od ce holob ilde...

Actin and myosin of rabbit pulmonary macrophages are influenced by two other proteins. A protein cofactor is required for the actin activation of macrophage myosin Mg2 ATPase activity, and a high molecular weight actin-binding protein aggregates actin filaments (Stossel T.P., and J.H. Hartwig. 1975. J. Biol. Chem. 250:5706-5711)9 When warmed in 0.34 M sucrose solution containing Mg2-ATP and dit...