OBJECTIVES The purpose of this study was to test the feasibility of contrast pulse sequence (CPS) ultrasound imaging for high-resolution perfusion imaging after gene transfer (GT) for therapeutic angiogenesis. BACKGROUND Imaging modalities capable of accurate and feasible perfusion measurement are essential for the preclinical and clinical development of therapeutic angiogenesis. However, cur...

introduction: addiction is a habit or behavior that is often hard to quit. it is estimated that 190 million persons are substance users around the world. substance abuse creates tolerance after a while. shortly after taking the drug, a person will not enjoy as the beginning of its use that is why the amount of substance used is gradually increased. the purpose of this study was to find the reas...

Microbubble ultrasound contrast agents have been in clinical use for more than two decades, during which time their range of applications has increased to encompass echocardiography, Doppler enhancement, perfusion studies and molecular imaging, as well as a number of therapeutic applications including drug delivery, gene therapy, high-intensity focused ultrasound treatments and sonothrombolysis...

INTRODUCTION Neurovascular ultrasound is a non-invasive, portable and fast imaging method that, when performed by an experienced neurosonologist, offers reliable and reproducible information on the morphological and hemodynamic status of cervical and intracranial vessels. AIM To review the available evidence regarding the use of this tool in the approach to acute stroke. DEVELOPMENT Neurova...

The theoretical diffraction-limit of resolution for ultrasound imaging has recently been bypassed in-vitro and in-vivo. However, in the context of ultrasound therapy, the precision of therapeutic beams remains bound to the half-wavelength limit. By combining acoustic vaporization of composite droplets and rapid ultrasound monitoring, we demonstrate that ultrasound drug-delivery can be restricte...

In the 1950s, the brothers William and Francis Fry treated a number of patients for Parkinson’s disease by focusing high intensity ultrasound on the brains of patients after some part their skull was removed. Local thermal ablations were created in targeted areas of brain and these treatments were shown to be beneficial to the patients. At the same time, in the former USSR, the team of A.K. Bur...

The simulation of ultrasound wave propagation is of high interest in fields as ultrasound system development and therapeutic ultrasound. From a computational point of view the requirements for realistic simulations are immense with processing time reaching even an entire day. In this work we present a framework for fast ultrasound image simulation covering the imaging pipeline from the initial ...