The hallmark of living matter is the replication of genetic molecules and their active storage against diffusion. We implement both in the simple nonequilibrium environment of a temperature gradient. Convective flow both drives the DNA replicating polymerase chain reaction while concurrent thermophoresis accumulates the replicated 143 base pair DNA in bulk solution. The time constant for accumu...

p38α is considered as the key isoform involved in modulating inflammatory response in rheumatoid arthritis and inflammatory pain and is therefore a key target for compound screening in pharmaceutical industry. In this study we demonstrate the use of Microscale Thermophoresis to perform an essentially label-free measurements of small molecule binding to protein targets by using a competitive app...

In this paper, the problem of laminar nanofluid flow which results from the nonlinear stretching of a flat sheet is investigated numerically. In this paper, a modified variable physical properties model for analyzing nanofluids flow and heat transfer is introduced. In this model, the effective viscosity, density, and thermal conductivity of the solid-liquid mixture (nanofluids) which are common...

Emerging applications in nanomaterials processing are increasingly featuring multiple physical phenomena including magnetic body forces, chemical reactions and high temperature behavior. Stimulated by developing a deeper insight of nanoscale fluid dynamics such manufacturing systems, the current article, we study nanofluid along nonlinear porous stretching sheet with Arrhenius kinetics wall tra...

In the present article, we considered two-dimensional steady incompressible Oldroyd-B nanofluid flow past a stretching sheet. Using appropriate similarity variables, the partial differential equations are transformed to ordinary (similarity) equations, which are then solved numerically. The effects of various parameters, namely, Deborah numbers [Formula: see text] and [Formula: see text], Prand...

Thermophoresis depletes DNA from a heated spot. We quantify for the first time the thermal diffusion constant D(T)=0.4x10(-8) cm(2)/s K for DNA, using fluorescent dyes and laser heating. For 5 kB DNA we extrapolate a 1000-fold depletion from a temperature difference of 50 K. Surprisingly, convection generated by the same heating can turn the depletion into trapping of DNA. Trapped DNA can form ...

Enzymes have been recently found to exhibit enhanced diffusion due to their catalytic activities. A recent experiment [C. Riedel et al., Nature (London) 517, 227 (2015)] has found evidence that suggests this phenomenon might be controlled by the degree of exothermicity of the catalytic reaction involved. Four mechanisms that can lead to this effect, namely, self-thermophoresis, boost in kinetic...

This paper presents a unified theory of phoretic phenomena in single-component fluids. Simple formulas are given for the phoretic velocities of small inert force-free non-Brownian particles migrating through otherwise quiescent single-component gases and liquids and animated by a gradient in the fluid's temperature (thermophoresis), pressure (barophoresis), density (pycnophoresis), or any combi...

A theoretical model for nanofluid flow, including Brownian motion and thermophoresis, is developed and analysed. Standard boundary layer theory is used to evaluate the heat transfer coefficient near a flat surface. The model is almost identical to previous models for nanofluid flow which have predicted an increase in the heat transfer with increasing particle concentration. In contrast our work...

The nonequilibrium distribution of colloids in a polymer solution under a temperature gradient is studied experimentally. A slight increase of local temperature by a focused laser drives the colloids towards the hot region, resulting in the trapping of the colloids irrespective of their own thermophoretic properties. An amplification of the trapped colloid density with the polymer concentration...