1,3,4-Thiadiazole skeleton forms an integral part of various medicinal agents and depicts a vast array of biological activities such as antimicrobial, anti-inflammatory, analgesic, antileishmanial, antitumor, anti-tuberculosis, antileptic, antiviral and other activities. 1,3,4-Thiadiazole moiety has many desirable features which makes them pharmaceutically suitable as it can act as “hydrogen bi...

A condensation reaction of 2-amino-1,3,4-thiadiazole with 2-pyrrolecarboxaldehyde to form tridentate NNN donor Schiff base has been performed. The prepared Schiff base was further used for the formation of metal complexes having stoichiometry [M(L)(2)]X(n), where M=Cu(II) or Zn(II), L=N-(2-pyrrolylmethylene)-2-amino-1,3,4-thiadiazole, X=SO(4) (2-), NO(3) (-), C(2)O(4) (2-) or CH(3)CO(2-) and n=...

The introduction of a low band-gap oligomer, oligo(benzo[1,2,5]thiadiazole-alt-3,3'''-dihexylquaterthiophene) (BT4T) improved the performance of P3HT:PCBM bulk heterojunction organic photovoltaic cells due to improved UV-vis absorption and increased P3HT crystallinity.

HIE-124 is a new member of ultra-short acting hypnotics’ drug family. In this research, the synthesis ofanalogues of HIE-124 drug in the heterocyclic thiazole ring replaced to thiadiazole, will be presented.Thiadiazolodiazepines during a two-step reaction starting from the amino thiadiazole resultedfrom-various derivatives of benzoic acid and thiosemicarbazide were synthesized. In the first ste...

A new electrochromic copolymer based on 4,7-di(thiophen-2-yl)benzo[c] [1,2,5]thiadiazole and 3,4-ethylenedioxythiophene was successfully obtained via the electrochemical polymerization method in medium of electrolyte solution, which consists 0.1 M tetrabutylammonium hexafluorophosphate dichloromethane. In order to compare chemical properties copolymer, benzothiodiazole derivative (EDOT) monomer...

The syntheses of two new ligands, 3,4-di(2-pyridyl)-1,2,5-oxadiazole (dpo) and 3,4-di(2-pyridyl)-1,2,5-thiadiazole (dpt), are described. Complexes with palladium and copper have seven-membered chelate rings with coordination through the two pyridine nitrogens, whereas in the silver nitrate complex of dpt the ligand acts as a bridge between metal centres. Studies of the mononuclear ruthenium com...

The influence of a structural modification on thermodynamic aspects of solubility and hydration processes of 1,2,4-thiadiazole drug-like compounds was investigated. A substitution in the phenyl ring of the 1,2,4-thiadiazole molecule leads to a significant decrease of the solubility of these compounds. In order to rationalize the relationship between the structures of 1,2,4-thiadiazoles and thei...

Several compounds were administered to pregnant Wistar-derived rats either 24 or four hours prior to the recovery of day 10 embryos for in vitro culture in Waymouth's medium and fetal calf serum. The compounds tested were 2-amino-1,3,4-thiadiazole (thiadiazole), cadmium sulfate, 1,2-dibromo-2,2-dichloroethyl dimethyl phosphate (dibrom), 2-(sec-Butyl)-4,6-dinitrophenol (dinoseb), led nitrate, po...

Objective: Tuberculosis, known in short as TB, is considered to be a global crisis caused by Myco bacterium tuberculosis, and which continues serious challenge public health world wide especially the developing countries. A problem related tuberculosis development of drug resistant strains.
 Methods: Present study describes synthesis eight novel derivatives 1,3,4-thiadiazole vitro evaluati...