Genetically encoded fluorescent protein tags have revolutionized proteome studies, whereas the lack of intrinsically fluorescent RNAs has hindered transcriptome exploration. Among several RNA-fluorophore complexes that potentially address this problem, RNA Mango has an exceptionally high affinity for its thiazole orange (TO)-derived fluorophore, TO1-Biotin (Kd ∼3 nM), and, in complex with relat...

In the present work, we have synthesized thiazole-hydrazone conjugates 5(a–h) and characterized them using various analytical techniques such as UV, IR, NMR, mass spectrometry. Solvatochromic properties were evaluated in ten solvents with different polarity quantum chemical parameters a DFT study. The antibacterial activity results revealed that compounds 5c, 5d 5g exhibited good efficacy remai...

The synthetic utility of 3,3'-(3,4-dimethylthieno[2,3-b]thiophene-2,5-diyl)bis (3-oxopropanenitrile) (1) in the synthesis of some novel bis-[1,3,4-thiadiazole] 6a-g and bis-thiazole 10 and 13 derivatives with thieno[2,3-b]thiophene moiety is reported. Antimicrobial evaluation of some selected examples from the synthesized products was carried out and showed promising results.

Simple three-component reactions between dialkyl acetylenedicarboxylate, primary amines and isothiocyanates in the presence of catalytic amount of ZnO nanorods are investigated in water at room temperature which produced thiazole derivatives in good yields.

Sources of Compounds Tested-Thiamine hydrochloride (Merck, U.S.P. grade), 0-acetylthiamine hydrochloride and oxythiamine dihydrochloride (California Foundation for Biochemical Research), pyrithiamine hydrobromide and 4-amino-5 aminomethyl-a-methyl pyrimidine dihydrochloride (Nutritional Biochemicals Corporation) were all used without further purification. For determination of pK, values, the 4-...

Thiamine pyrophosphate is required as a coenzyme for several enzymatic reactions which result in the decarboxylation of cu-keto acids with the concomitant formation of corresponding aldehydes or their condensation products (a-keto alcohols). A number of investigators (l-3) have found that thiamine will catalyze the same reactions under mildly alkaline conditions in the absence of enzymes. This ...