Recently we reported the preparation and properties of some 2-(2or · 3-furyl)benzothiazoles1• Like many other thiazoles2 , due to their weak basic character they can give quaternary salts. Comparing 2-(2-methyl-3-furyl)benzothiazoles with the 2-(5-methyl-2-furyl) analogue it was observed that the nucleophilicity (and basicity) of benzothiazole nitrogen is influenced by the position of the methy...


 1,3-Thiazole is one of the most attractive cores in heterocycles chemistry and drug discovery. Its widespread use diverse medicinal substances makes thiazole a versatile scaffold, which leads to novel generation efficient pharmaceuticals. This study was intended synthesize series N,N-disubstituted aminothiazole derivatives having various fragments at 4th 5th positions ring. The formation...

Synthesis and preliminary biological evaluation of imidazo (2, 1-b) Thiazole derivatives is reported. Under Mannich conditions, a series new were synthesized. Starting from the reaction 2- amino thiazole with 4- bromo phenyl bromide to produce 5-(4-bromo phenyl) thiazoles, following by introduce substituted aminomethyl at position 6-by reacting different aromatic amines under conditions afford ...

The pathway of thiamine biosynthesis in Escherichia coli from its pyrimidine and thiazole moieties involves four enzymes (Y. Nose et al., J. Vitaminol. Kyoto 10:105, 1964): hydroxymethylpyrimidine kinase (EC 2.7.1.49), phosphohydroxymethylpyrimidine kinase (EC 2.7.4.7), thiazole kinase (EC 2.7.1.50), and thiamine phosphate pyrophosphorylase (EC 2.5.1.3). A mutant of E. coli W auxotrophic for th...

New series of thiazole derivatives were synthesized using 5-(aryldiazo)salicylaldehyde thiosemicarbazones 2a–i. Cyclocondensation 2a–i with chloroacetone afforded the corresponding 4-methylthiazole 3a–i. Moreover, cycloalkylation ethyl bromoacetate thiazolidin-4-one 4a–i. The antimicrobial activity new was evaluated.

Several analogues of thiamine’ are known to compete with the vitamin when administered to animals. Thus, Woolley and White (1) have observed that pyrithiamine caused the manifestation of typical thiamine deficiency symptoms, which could be competitively overcome by the vitamin. The antivitamin effect of oxythiamine in mice has been reported by Soodak and Cerecedo (2). Cerecedo et al. (3, 4), co...

BACKGROUND Many heterocyclic compounds containing thiazole or 1,3,4-thiadiazole ring in their skeletons have been reported to possess various pharmacological activities especially anticancer activities. RESULTS 4-Methyl-2-phenylthiazole-5-carbohydrazide (2) was used as a synthon to prepare 2-(4-methyl-2-phenylthiazole-5-carbonyl)-N-phenylhydrazinecarbothioamide (3) and 2-(2-(4-methyl-2-phenyl...

Several novel N-(4,5-diphenylthiazol-2-yl)-N'-aryl or alkyl (thio)ureas and N-(4,5-diphenylthiazol-2-yl)alkanamides were prepared as potential acyl-CoA: cholesterol O-acyltransferase (ACAT) inhibitors. Synthesis was accomplished by reaction of 2-amino-4,5-diphenylthiazole with the suitable isocyanate, isothiocyanate or acyl chloride. Some analogues without the 5-phenyl substituent or both the p...

A series of new hexahydroquinoline and 1,4-dihydropyrimidine derivatives were synthesized. Condensation of 2-methyl- thiazole-4-carboxaldehyde (1) with 1,3-cyclohexanedione and alkyl 3- aminocrotonate afforded 4-(2-methyl-thiazol-4-yl)-hexahydroquinoline while condensation of aldehyde (1) with benzoyl acetone and thiourea gave 1,4-dihydropyrimidine derivatives. The stereochemistry of 1,4-dihydr...