BACKGROUND Findings from a recent large study suggest that perchlorate at commonly occurring exposure concentrations may decrease thyroid hormone levels in some women. Decreases in thyroid hormone seen with perchlorate exposure could be even greater in people with concomitant exposure to agents such as thiocyanate that may affect the thyroid by mechanisms similar to those of perchlorate. OBJE...

The degradation capacity of a mixed culture of Agrobacterium tumefaciens SUTS 1 and Pseudomonas monteilii SUTS 2 for thiocyanate and metal cyanide, in the form of zinc and cadmium, has been determined. The growth of a mixed culture of SUTS 1 and SUTS 2 in cyanide complexes and the cyanide removal efficiency of a fixed-film bio-column system were studied. The results showed that the mixed cultur...

Hydrogenase pleiotropically acting protein (Hyp)E plays a role in biosynthesis of the cyano groups for the NiFe(CN)2CO center of [NiFe] hydrogenases by catalyzing the ATP-dependent dehydration of the carbamoylated C-terminal cysteine of HypE to thiocyanate. Although structures of HypE proteins have been determined, until now there has been no structural evidence to explain how HypE dehydrates t...

OBJECTIVE To study the relative importance of determinants of thyroid volume. DESIGN Cross-sectional study on a sample of subjects issued from the SU.VI.MAX cohort. SUBJECTS 2987 French subjects (1713 women aged 35-60 years and 1274 men aged 45-60 years). None of them had previous or present thyroid disease. MEASUREMENTS Thyroid volume was determined by ultrasound. Serum TSH and free thyr...

the antioxidant properties of ruta graveolens l. were evaluated by two different methods; free radical scavenging using dpph and inhibition of lipid peroxidation by the ferric thiocyanate method. the ic50 value of the methanol extract in dpph inhibition was 200.5 μg/ml which was acceptable in comparison with bht (41.8 μg/ml). in thiocyanate method, the plant extract demonstrated activity as muc...