BACKGROUND AND PURPOSE Sublethal injury induces tolerance to a subsequent lethal insult, a phenomenon termed preconditioning (PC). PC occurs within hours (early tolerance) or days (delayed tolerance) after the inducing stimulus. In the brain, delayed tolerance has been studied extensively, but very little is known about early tolerance. We investigated whether the proinflammatory agent lipopoly...

The methods followed for morphological, cultural, and biochemical identification were essentially those recommended for Moraxella (2). Locomotion was studied with a modified moist chamber technique (9), by using the medium of Halvorsen (5) with 10% (v/v) horse serum. To study cell habit and the cytoplasmic structure, cells were fixed in situ through the agar with Bouin's fluid (8), stained with...

a potent inhibitor of the putrescine-activated S-adenosylrne thionine decarboxylase (44), can specifically block the synthe sis of spermidine and spermine both in vivo (30) and in vitro in tissue-cultured cells (11, 35). This study describes the exten sion of our original studies with normal rat fibroblasts (35) to a detailed comparison of the effects of MGBG on a normal mouse fibroblast cell l...

Genetic deletion of NMDA glutamate receptors disrupts development of whisker-related neuronal patterns in the somatosensory system. Independent studies have shown that NMDA receptor antagonists increase cell death among developing neurons. Here, we report that a dramatic feature of the developing somatosensory system in newborn NMDA receptor 1 (NMDAR1) knock-out mice is increased cell death in ...

muscle, which is particularly great with DNP. Further experiments on these problems are in progress. SUMMARY 1. The influence of 2:4-dinitrophenol, methylene blue, brilliant cresyl blue, thionine, phenosafranine and Janus Green B on the oxidative phosphoryl-ation of mitochondria isolated from liver, kidney, brain, heart and skeletal muscle of rats has been studied in vitro as well as in vivo. 2...

Layer charge is one of the key parameters used for the characterisation of expandable clay minerals, smectites. It determines most significant properties of the material which are important from the industrial application point of view. This work is related to a novel method introduced to characterize the layer charge of smectites, based on using cationic organic dyes as molecular sensors. One ...

Liveborn children delivered at Queen Charlotte's Hospital were studied between February 1962 and July 1963 and those born at Guy's from February 1962 onwards. A group of 9688 babies has been studied to date, comprising 4754 girls and 4934 boys. The sex chromatin findings (based on thionine or Feulgen stained oral smears) are presented in Table I, where they are also compared with published data...

Dual action antidepressants have important therapeutic implications. Methylene blue (MB), a charged compound structurally related to tricyclic antidepressants, acts on both monoamine oxidase (MAO) and the nitric oxide (NO)-cGMP pathway, and has demonstrated antidepressant activity in rodents. We investigated the antidepressant properties of MB and selected structural analogues and whether their...

Abstract Alfalfa expresses significantly distinct sets of genes in response to infection with different rhizobial strains at the below species level (i.e., biotype or strain). However, differences transcriptomic profiles two alfalfa cultivars nodulated by a single rhizobium strain have been largely unexamined. In this study, comparative RNA-seq analysis cultivars, Medicago sativa cv. Gannong No...