introduction: physicians frequently deal with procedures which require sedation of pediatric patients. laceration repair is one of them. no study has been performed regarding the comparison between induction of sedation with sodium thiopental and ketamine in laceration repair. therefore, the present study was aimed to comparison of induced sedation by rectal sodium thiopental and muscular injec...

A general, simple, practical and convenient method has been described for the synthesis of anesthetic drug thiopental using thiourea in the presence of sodium ethoxide. Anesthetic drug of thiopental was prepared in two stages; during the first stage, the alkylation of mthyl cyanoacetate was performed which was then to be followed by cyclization. Alkylation of methyl cyanoacetate which was perfo...

In vitro effects of dihydroergotoxine, dihydroergosine, dihydroergotamine, alpha-dihydroergocriptine (ergot alkaloids), diazepam, methyl-beta-Carboline-3-carboxilate (beta-CCM), flumazenil (benzodiazepines), gamma-amino butyric acid (GABA) and thiopental (barbiturate) were studied on mouse brain (cerebrum minus cerebral cortex) benzodiazepine binding sites labeled with 3H-flunitrazepam. Specifi...

Thiopental, monosodium 5-ethyl-5(1-methylbutyl) -thiobarbiturate, is extensively used in clinical anesthesia either as a primary anesthetic agent for short surgical procedures or as a supplementary drug in conjunction with other anesthetics. Fatalities have been attributed to its use (1, 2) and cardiac arrest has occurred following its administration to patients under spinal anesthesia (3). Mos...

An accurate, sensitive, and specific gas-liquid-chromatographic procedure is described for determining concentrations of thiopental in human plasma. After a double extraction of 0.2 or 1.0 mL of plasma containing phenobarbital as an internal standard, thiopental and the internal standard are derivatized in a polar non-aqueous solvent system with iodomethane. The reaction mixture is then evapora...

Following a single administration of sodium thiopental in high doses (85 mg/kg intraperitoneally), the animals demonstrated absence or weakening reflexes at levels spinal cord, medulla oblongata, bridge and midbrain cerebral cortex over period one day. Other signs included pronounced hypothermia, decrease respiratory rate violation its rhythm, distinct tendency to bradycardia. On days 1-3 after...

In Cook v. FDA,1 the US Court of Appeals for the District of Columbia Circuit unanimously affirmed a March 2012 decision by the DC District Court permanently enjoining the Food andDrug Administration (FDA) from permitting the entry of foreign manufactured sodium thiopental (thiopental) into interstate commerce. The decision is a serious setback for the FDA’s use of its enforcement discretion.Co...

BACKGROUND We tested the effect of thiopental on the excitability of the corticospinal-motoneuron axis in normal human subjects. METHODS Magnetic stimulation was used to excite the neurons in the motor cortex which give rise to the fast conducting corticospinal pathway. The characteristics of the composite excitatory post-synaptic potentials (EPSPs) produced in individual spinal motoneurons b...

Pulmonary veins (PV) make a significant contribution to total pulmonary vascular resistance. We investigated the cellular mechanisms by which the intravenous anesthetics propofol and thiopental alter adenosine triphosphate-sensitive potassium (KATP+) channel relaxation in canine PV. The effects of KATP+ channel inhibition (glybenclamide), cyclooxygenase inhibition (indomethacin), nitric oxide s...