Defective placentation and subsequent placental insufficiency lead to maternal and fetal adverse pregnancy outcome, but their pathologic mechanisms are unclear, and treatment remains elusive. The mildly hypertensive BPH/5 mouse recapitulates many features of human adverse pregnancy outcome, with pregnancies characterized by fetal loss, growth restriction, abnormal placental development, and def...

BACKGROUND  Neuro-inflammatory circuits in the tissue regulate the complex pathophysiology of pain.  Protective nociceptive pain serves as an early warning system against noxious environmental stimuli.  Tissue-resident mast cells orchestrate the increased thermal sensitivity following injection of basic secretagogue compound 48/80 in the hind paw tissues of ND4 mice.  Here we investigated the e...

We report a case of paraplegia without neurologic deficit of upper extremities following cervical epidural catheterization using air during the loss of resistance technique. A 41-year-old woman diagnosed with complex regional pain syndrome had upper and lower extremity pain. A thoracic epidural lead was inserted for a trial spinal cord stimulation for treating lower extremity pain and cervical ...

background and aims: kindling is regarded as an experimental model of temporal lobe epilepsy that reflects a process of progressive and persistent intensification of seizure. experimental and clinical evidence suggest that there is an interrelationship among epileptogenesis, local inflammation and antioxidant activity. in this study, the possible antioxidant and anti-inflammatory effects of thy...

Syringomyelia is a not infrequent pathology that develops related to changes in cerebrospinal fluid dynamics due to many etiological factors. The development of syringomyelia through a spinal arachnoid cyst is quite rare and has been defined in only 31 cases in the literature. A case due to thoracic epidural lipomatosis has also been reported. There have been no previous reports of thoracic reg...

conclusions the addition of tramadol to epidural 2% lidocaine offers advantages in cesarean section. results in the lt100 group, onset of complete sensory and motor blockade at t6 was less than in the two other groups, but the highest level of sensory blockade and two segment regression and duration of motor blockades between the lt50 and lt100 groups were not significantly different, although ...

Epidural analgesia has many beneficial effects in the pediatric patient population. In clinical practice, it is commonly used to augment general anesthesia and to manage postoperative pain. Introduction Epidural analgesia has many beneficial effects in the pediatric patient population. In clinical practice, it is commonly used to augment general anesthesia and to manage postoperative pain. Effe...

background: melatonin, a reactive oxygen species (ros) scavenger and an antioxidant, has been shown that can inhibit apoptosis. administration of melatonin may improve embryo development in assisted reproductive technology (art). objective: the aim of this study was to evaluate the role of melatonin in inhibition of spontaneous and induced apoptosis by tumor necrosis factor alph (tnf-α) and act...

background and aims. the role of cytokines in the immunopathogenesis of oral lichen planus (olp) has received much attention. the aim of this study was to evaluate the serum levels of tnf-α and tgf-β in patients with olp in an iranian population. materials and methods. thirty-two patients with olp and 32 age-matched healthy volunteers as a control group were included in this study. serum tests ...

مقدمه افزایش سن، سندروم متابولیک و عوامل التهابی از عوامل موثر در کاهش حجم مغز و افت عملکرد شناختی می باشد. هدف از این تحقیق بررسی اثرگذاری 12 هفته تمرین هوازی با شدت متوسط بر bdnf و tnf-α زنان 50-65 ساله مبتلا به سندروم متابولیک می باشد. روش کار این مطالعه به روش نیم تجربی و از نوع کاربردی با طرح پیش آزمون – پس آزمون و گروه کنترل در شهر زنجان درسال 1394 انجام شده است. 24 زن مبتلا به سندروم متا...