A thrombophilia is defined as a disorder of hemostasis that predisposes a person to a thrombotic event. Data suggest that at least 50% of cases of venous thromboembolism in pregnant women are associated with an inherited or acquired thrombophilia, which can lead to an increased risk of maternal thromboembolism and adverse pregnancy outcomes such as recurrent pregnancy loss, intrauterine fetal d...

© 2002 Blackwell Science Ltd ‘I call him a perfect physician who judges it better to abstain from treatment than pursue one which might perturb the course of the malady’ (Maimonedes, 1125–1204). This might well apply to long-term anticoagulation, with the inevitable risk of bleeding, in a patient with deep venous thrombosis who is found to have factor V Leiden. There is no evidence that the ris...

Thrombophilic risk factors are common and can be found in 15% to 25% of Caucasian populations. Since pregnancy is an acquired hypercoagulable state, women harboring thrombophilia may present with clinical symptoms of vascular complications for the first time during gestation or at the postpartum period(1). Women with thrombophilia may have an increased risk of placental vascular complications, ...

INTRODUCTION: Thrombophilia is the increased tendency to form thrombi, often silent, usually due to genetic mutations. Venous thrombosis has an incidence of 0.1% in the general adult population. Deep vein thrombosis (DVT) with pulmonary emboli (PE), collectively called venous thromboembolism (VTE), can be fatal in up to 25% of patients with PE. Case review of two brothers with both familial mul...

The development of venous thromboembolism (VTE), which includes deep-vein thrombosis and pulmonary embolism, may be associated with inherited or acquired risk factors that can be measured in plasma or DNA testing. The main inherited thrombophilias include the plasma deficiencies of the natural anticoagulants antithrombin, protein C and S; the gain-of-function mutations factor V Leiden and proth...

There is a paucity of strong evidence associated with adverse pregnancy outcomes and thrombophilia in pregnancy. These problems include both early (recurrent miscarriage) and late placental vascular-mediated problems (fetal loss, pre-eclampsia, placental abruption and intra-uterine growth restriction). Due to poor quality case-control and cohort study designs, there is often an increase in the ...

From the 'Channg Cross and Westminster Medical School London UK IRCCS Maggiore Hospital, Milan Italy Beth Israel Hospital, Boston USA, "University Hospital Leiden The Netherlands Research Centre of Medical Genetics Moscow The Russian Federation, WHO, Switzerland, Chnstian Medical College Hospital Vellore India University of Lund, Malmo Sweden 'Institute of Clinical Genetics Moscow The Russian F...