The thrombophilia represent a spectrum of coagulation disorders associated with a predisposition for thrombotic events (deep vein thrombosis (DVT) and pulmonary embolism (PE)) (Kaandorp et al, 2009). Inherited thrombophilia include a single-point mutation on the Factor V gene (factor V Leiden (FVL), prothrombin (PT) G20210A gene mutation, deficiencies in protein C and protein S as well as antit...

Pregnancy is a hypercoagulable state associated with an increased risk of venous thromboembolic disease (VTE). We retrospectively studied 38 Caucasian pregnant women with thrombophilia risk and compared their obstetric outcomes with a matched cohort without known thrombophilia risk during the period between January 2007 and December 2010. There were (2) cases with factor V Leiden, (6) prothromb...

The role of thrombophilia in the pathogenesis of preeclampsia is controversial. The aim of this case-controlled study was to determine whether thrombophilia increases the risk of preeclampsia or interferes with its clinical course. A total of 808 white patients who developed preeclampsia (cases) and 808 women with previous uneventful pregnancies (controls) matched for age and parity were evalua...

Venous Thrombosis is a major cause of mortality and morbidity in Western populations and in 30% of cases is associated to genetic susceptibility. Ideally, the identification of carriers of such susceptibility, known as thrombophilia, may allow for predicting the likelihood of recurrence in symptomatic patients and the risk of thrombosis in their relatives, leading to tailored plans of therapy a...

Acute mesenteric venous thrombosis (MVT) is an uncommon form of intestinal ischemia with high mortality and usually occurs in the setting of preexisting comorbidities including thrombophilia and abdominal inflammatory conditions. Hyperhomocysteinemia has been known to be a risk factor for thromboembolism, often located on an unusual site. Considering that homocysteine metabolism is determined g...

Thrombophilia can be defined as a predisposition to form clots inappropriately. Thrombotic events during infancy and childhood are increasingly recognized as a significant source of mortality and morbidity. The predisposition to form clots can arise from genetic factors, acquired changes in the clotting mechanism, or, more commonly, an interaction between genetic and acquired factors. Since the...

Coagulation parameters were studied in a population of 118 children with Perthes disease in order to determine the possible role of thrombophilia as a causative factor for the disease and to determine if thrombophilia could affect its course. We found 27 children presenting one or more coagulation disorders. The statistical analysis concurs with previous findings of a relationship between Legg-...

Congenital and acquired thrombophilias are the most common predisposing factors for thromboembolism, but they may also contribute to pathophysiological processes involved in recurrent pregnancy loss, fetal death, intrauterine growth restriction, placental abruption, placental infarction, and pre-eclampsia. The most common thrombophilias are deficiencies of antithrombin III, protein C, and prote...

BACKGROUND/AIM To examine the relationship of inherited thrombophilia and other thrombotic risk factors with preeclampsia (PE) in a population of pregnant Turkish women. MATERIALS AND METHODS This was a case cross-sectional study in which 70 women with PE and 60 normal pregnant women were studied to find out the frequency of women with risk factors including inherited thrombophilia among pree...

OBJECTIVES To assess whether thrombophilia testing following a venous thrombotic event is clinically effective and cost-effective in the management of thrombosis compared with no testing for thrombophilia. DATA SOURCES Major electronic databases were searched from September to November 2006. REVIEW METHODS A systematic review of the clinical effectiveness and cost-effectiveness literature w...