This prospective case-controlled study investigated the role of the pituitary-thyroidal axis in the prediction of mortality in dogs. Serum thyrotropin, thyroxine and free thyroxine were measured at admission and daily until death or discharge in dogs ill with parvoviral diarrhoea. Serum thyroxine and free thyroxine in ill dogs were significantly lower than in controls and also significantly low...

We assessed the efficacy of a new thyroxine radioimmunoassay kit (Abott) in which polyethylene glycol is used to separate bound from free hormone. Mean serum thyroxine was 88 +/- 15 (+/-SD) microgram/liter for 96 normal persons. Results for hypothyroid and hyperthyroid persons were clearly separated from those for normal individuals. Women taking oral contraceptive preparations showed variable ...

Subcutaneous administration of L-thyroxine (75 pg/lOO g of body weight per day) to rats for 10 to 14 days caused a decrease in the activity of kynurenine 3-hydroxylase to about 50% of the control value. Enzymic properties of kynurenine 3-hydroxylase of mitochondrial outer membrane preparations isolated from normal and L-thyroxine-treated rats were almost identical, suggesting that L-thyroxine a...

BACKGROUND Levothyroxine (l-thyroxine) intoxication may arise from intentional or accidental ingestion of excessive doses of the hormone and may cause symptoms equivalent to thyroid storm. We report a case of massive accidental l-thyroxine intoxication resulting from an error in the preparation of capsules to treat goiter. SUMMARY A 61-year-old woman was admitted showing high levels of thyroi...

Serum thyroid stimulating hormone and thyroxine concentrations were monitored in 42 infants who had been treated for congenital hypothyroidism. Serum thyroid stimulating hormone concentrations were raised in 22 of the infants (52%) at 2 to 4 months, in 16 (38%) at 5 to 11 months, in 14 (33%) at 12 to 18 months, and in eight (19%) at 2 to 4 years. Serum thyroxine and the dose of L-thyroxine/kg/b...

Since thyroxine, uncombined in peptide linkage, has been detected by isotope dilution and paper chromatography in thyroid tissue (1, 2) and in plasma (l-3), it is likely that this substance is the hormonal secretion of the thyroid gland. Previously, the fate of labeled thyroxine has been determined after the injection of large amounts (4-6), considerably in excess of the few micrograms which co...

BACKGROUND AND OBJECTIVES Treatment of hypothyroid pregnant women is usually calculated based on weight (1 μg/kg/day) and TSH levels. This study assessed the usefulness of treating these women with a fixed dose of 75 μg/day. PATIENTS AND METHODS All women with pregnancy diagnosed from January to August 2012 in the Vigo Health Area (Spain) without previous diagnosis of thyroid disease or thyro...

Studies were carried out to determine the chemical structures of thyroxine metabolites after total deiodination. Normal subjects were given thyroxine labeled with (14)C on the nonphenolic ring and the alanine side chain, 8-11 mug/day for 10 days. By paper chromatography of fresh urine, six or more (14)C-labeled compounds were separated. The (14)C-labeled metabolites were concentrated by passing...