We compared the free-thyroxine index in normal adults and in euthyroid patients taking diphenylhydantoin. All subjects had normal serum thyrotropin concentrations. Serum thyroxine concentrations were determined by two commonly used competitive protein-binding assays, which yielded slightly different values, but which consistently showed the same degree of decrease in mean serum thyoxine concent...

Thyroxine is an important hormone related to growth. To study the effects of thyroxine on serum levels of insulin-like growth factor I (IGF-I), anthropometric measures, and body composition, we studied 28 patients who were receiving thyroxine therapy after thyroidectomy for well-differentiated thyroid cancer. Serum IGF-I levels decreased from 38.3 +/- 19.0 ng/ml (mean +/- SD) to 26.8 +/- 12.8 n...

Thyrotoxicosis is a condition of excess circulating thyroid hormones. Maternal thyrotoxicosis has been related to the development craniosynostosis (CS) in approximately 3% births. CS occurs when cranial sutures skull fuse prematurely. However, mechanism for hormone-induced those cases unclear. Currently, we are establishing an avian model thyroxine-induced study these mechanisms. Two groups fer...

on thyroxine-binding proteins (UTBP), T4 bound to thyroxine-binding proteins (PBI or TBPT4) andfree thyroxine (FT4). thyroid status. This is shown in diagrammatic fashion in fig 1 which illustrates the changes that occur in thyrotoxicosis and hypothyroidism and in those situations where there are alterations in thyroxine-binding protein capacity, such as the increase in thyroxine-binding globul...

Indices of thyroid function were measured in 229 healthy term neonates at birth and at 5, 10, and 15 days of age. Results were analysed to assess whether maternal diabetes mellitus, toxaemia of pregnancy, intrapartum fetal distress, duration of labour, method of delivery, asphyxia at birth, race, sex, birthweight, birth length, head circumference, or method of feeding influenced any index. Thyr...

SYNOPSIS A trial was carried out on 134 patients of new kits (Ames Co) using columns of Sephadex G-25 for the determination of serum total thyroxine (Tetralute test) and for the indirect estimation of serum free thyroxine-binding globulin capacity (Trilute test). Both new methods were quicker and easier than the reference resin methods and of similar precision. The two measurements when combine...

OBJECTIVES To determine whether thyroxine treatment is effective in patients with symptoms of hypothyroidism but with thyroid function tests within the reference range, and to investigate the effect of thyroxine treatment on psychological and physical wellbeing in healthy participants. DESIGN Randomised double blind placebo controlled crossover trial. SETTING Outpatient clinic in a general ...

To characterize changes in rates of protein turnover during regression of thyroxine-induced left ventricular hypertrophy, New Zealand White rabbits received intravenous thyroxine (200 micrograms/kg/d) for 9 days. Thyroxine was withheld, and in vivo protein turnover was evaluated on the 10th, 15th and 20th days. Animals not receiving thyroxine served as controls. Heart rate, blood pressure, and ...