The metabolism of anti-breast cancer drug, tamoxifen, in a single human hepatocellular carcinoma cell, HepG2, was directly monitored by a video-mass spectroscope. The cytoplasm, a vacuole or nucleus of the cell was directly sucked by a nano-spray tip under a video-microscope, and then was introduced into a mass spectrometer. Unchanged drug molecules were found in cytoplasm and a vacuole, but ...

3D-printed cartridges were designed and fabricated to improve the paper spray ionization method for mass spectrometry (MS). The cartridges protect the fragile paper material, stabilize the tip to prevent warping and misalignment and facilitate interfacing with mass spectrometry. Most importantly, the cartridge enables sophisticated control over solvent flows. Integrated wetting features enable ...

The Baade’s Windows of low obscuration towards the inner parts of the Galactic bulge represent ideal places in which to develop an understanding of the ISOGAL colour-magnitude diagrams. Unlike the case for the solar neighbourhood, their contents are at a uniform distance from the Sun, affected only by the finite thickness of the Bulge. The objects detected in the ISOGAL survey are found to be l...

In this study, we systematically investigate deformed Xe–Xe collisions at 5.44 TeV center of mass energy. We exploit Monte Carlo HYDJET++ model to compute transverse momentum ( $$p_{T}$$ ) distribution, nuclear modification factor $$R_{AA}$$ and relative suppression in terms $$R_{CP}$$ as a function centrality collision charged hadrons body–body tip–tip geometrical configurations, respectively....

peach (prunus persica l. batsch.) is produced in most areas of iran, where flowering is hindered by temperature. using plant growth regulators to delay bloom is a suggestive measure to avoid frost damage. the objective of this study was to determine the effects of methyl jasmonate (mj) and salicylic acid (sa) on peach bloom delay and yield.  this study evaluated the applications of mj 0 (contro...

Pb islands grown on a Si substrate transform at room temperature from a flattop facet geometry into an unusual ring shape. The volume-preserving mass transport is catalyzed by the electrical field from the tip of a scanning tunneling microscope. The ring morphology results from the competing classical and quantum effects in the shape relaxation. The latter is enhanced by the large anisotropy of...