Regenerative medicine is a rapidly advancing field that uses principles of tissue engineering, developmental biology, stem cell biology, immunology, and bioengineering to reconstruct diseased or damaged tissues. Biologic scaffolds composed of extracellular matrix have shown great promise as an inductive substrate to facilitate the constructive remodeling of gastrointestinal (GI) tissue damaged ...

In spinal cord injuries, direct trauma by edges of sublaxated or dislocated vertebrae and indirect ischemia as a result of vascular injury necrotize the neural tissue. After spinal cord injury, tissue loss appears as micro- or macrocavitation. Accumulations of non-neuronal cells substitute spared tissue and halts axon regrowth. Lack of supporting cells (secreting trophic factors and matrix) agg...

BACKGROUND AND OBJECTIVE Matrix metalloproteinases are associated with matrix turnover in both physiological and pathological conditions. We postulate an association between aberrant matrix metalloproteinases proteolytic activity and the intestinal tissue destruction, seen in patients with Crohn's disease and/or ulcerative colitis. MATERIALS AND METHODS Surgically resected inflamed and non-in...

Introduction Perforation of maxillary sinus mucous membrane is of the most prevalent complication during open sinus lift surgery. Moreover, such complication can usually be managed by an absorbable membrane. As far as absorbable membranes are concerned, decellularized maxillary sinus mucous membranes, which is an extracellular matrix, can be used as a biologic scaffold and insulating membrane ...

scaffold design has pivotal role in tissue engineering. in the present study, we modified the surface of electrospun poly(caprolactone) (pcl) nanofibers to improve their compatibility with living medium and to show the potential application of pcl nanofibers as a artificial extracellular matrix using in tissue-engineering. pcl nanofibers were fabricated by electrospinning method. to graft gelat...

background: the association between interleukin‑6 (il‑6) (‑174g/c) gene polymorphisms and level of tissue breakdown and periodontal disease progression is unknown. the present study investigated quantitative parameters of interdental papilla in chronic periodontitis (cp) patients with il‑6 (‑174g/c) gene polymorphisms. materials and methods: sixty gingival samples were studied. after determinat...