Dorsal cell fate in Drosophila embryos is specified by an activity gradient of Decapentaplegic (Dpp), a homologue of bone morphogenetic proteins (Bmps) 2/4. Previous genetic and biochemical studies have revealed that the Sog, Tsg and Tld proteins modify Dpp activity at the post-transcriptional level. The predominant view is that Sog and Tsg form a strong ternary complex with Dpp that prevents i...

BACKGROUND Industrial radiography is known to be one of the most vulnerable lines of work among the range of different radiation work. According to the relevant law in Korea, every worker registered in this work should check their blood cell counts every year in addition to their thermoluminescent dosimeter (TLD) doses. Since the law was enacted, however, few follow-up studies have been carried...

BMP signaling is modulated by a number of extracellular proteins, including the inhibitor Chordin, Tolloid-related enzymes (Tld), and the interacting protein Twisted Gastrulation (Tsg). Although in vitro studies have demonstrated Chordin cleavage by Tld enzymes, its significance as a regulatory mechanism in vivo has not been established in vertebrates. In addition, Tsg has been reported in diff...

BACKGROUND Dose assessment using proper dosimeters is especially important in radiation protection optimization and imaging justification in diagnostic radiology. OBJECTIVE The aim of this study is to obtain the Entrance Skin Dose (ESD) of patients undergoing lumbar spine imaging using two thermoluminescence dosimeters TLD-100 (LiF: Mg, Ti) and GR-200 (LiF: Mg, Cu, P) and also to obtain the a...

Drosophila metalloproteinase Tolloid (TLD) is responsible for cleaving the antagonist Short gastrulation (SOG), thereby regulating signaling by the bone morphogenetic protein (BMP) Decapentaplegic (DPP). In mice there are four TLD-related proteinases, two of which, BMP1 and mammalian Tolloid-like 1 (mTLL1), are responsible for cleaving the SOG orthologue Chordin, thereby regulating signaling by...

PURPOSE Analyze the characteristics of TLD LiF-100 powder between multiple LiF crystal batches. METHODS The RPC used TLD LiF-100 encapsulated powder to verify the output for photon and electron beams for 4 to 23 MV X-ray beams and 6 to 23 MeV electron beams, respectively, from the past 15 years. During that time period, the RPC commissioned more than 15 batches of TLD powder. Commissioning of...

Inhibition of DNA replication with hydroxyurea during thymine starvation of Escherichia coli shows that active DNA synthesis is not required for thymineless death (TLD). Hydroxyurea experiments and thymine starvation of lexA3 and uvrA DNA repair mutants rule out unbalanced growth, the SOS response, and nucleotide excision repair as explanations for TLD.

BACKGROUND Parasympathetic pulmonary nerves release acetylcholine that induces smooth muscle constriction. Disruption of parasympathetic pulmonary nerves improves lung function and COPD symptoms. AIMS To evaluate 'targeted lung denervation' (TLD), a novel bronchoscopic therapy based on ablation of parasympathetic pulmonary nerves surrounding the main bronchi, as a potential therapy for COPD. ...

Context: Test-Driven development (TDD) is a software development approach where test cases are written before actual development of the code in iterative cycles. TDD has gained attention of many software practitioners during the last decade since it has suggested several benefits in the software development process. However, empirical evidence of its dominance in terms of internal code quality,...

INTRODUCTION The angular dependency of response for TLD cards may cause deviation from its true value on the results of environmental dosimetry, since TLDs may be exposed to radiation at different angles of incidence from the surrounding area. OBJECTIVE A 3D setting of TLD cards has been calibrated isotropically in a standard radiation field to evaluate the improvement of the accuracy of meas...