rheumatoid arthritis is the most common inflammatory joint disease with 1 percent prevalence in community which presents with symmetrical polyarthritis of hands with inflammatory behavior. several studies in recent years were conducted for evaluation of inflammatory cytokines such as il1-α (interlukin 1α) and tnf- α (tumor necrosis factor) in rheumatologic disorders including rheumatoid arthrit...

conclusions the current study adds evidence to the association of tnf-α gene polymorphism and ms in this southern south iranian population which is consistent with the genetic analysis of ms in europeans (games) project reports and these two alleles reported in this study may be one of the genetic risk factor for ms. furthermore, this data can be used to build the iranian gene bank for future s...

introduction: the systemic and local content of inflammatory cytokines and chemokines play substantial roles in pathophysiology of arthritis. this study was purposed to verify the roles of synovial tnf-α, il-6 and fractalkine (fkn) in edema changes during different stages of complete freund’s adjuvant (cfa)-induced knee arthritis in rats. methods: 168 male wistar rats were divided in 7 groups a...

Tumor necrosis factor alpha (TNF-α) is a pro-inflammatory cytokine important in normal and pathological biological processes. Newly synthesized pro-TNF-α is expressed on the plasma membrane and cleaved to release soluble TNF-α protein: both are biologically active. Secreted TNF-α signals through TNF receptors and the membrane-bound TNF-α acts by cell contact-dependent signaling. Anti-TNF-α anti...

This study was aimed to monitor water pullution of Uzuncayir Dam Lake using the changes of IL-6, IL1β and TNF-α levels in Capoeta umbla (Heckel, 1843) liver tissue at ten stations in March and September 2011. In this study C. umbla (Heckel, 1843) was used as the indicator organism. Tumor necrosis factor-α (TNF-α), interlekuin1β (IL-1β) and interleukin-6 (IL-6) levels were determined in samples ...

Abstract Objective Acute lung injury (ALI) is characterized by inflammation and oxidative stress. Nuclear factor-kappaB (NF-κB) mediates the expression of various inflammation-related genes, including NADPH oxidase family. This study aimed to identify potential regulatory role NF-κB on oxidases in tumor necrosis factor-α (TNF-α)-induced stress human alveolar epithelial cells. Methods A549 cells...

BACKGROUND AND AIM: Recurrent aphthous stomatitis (RAS) is a lesion of the oral cavity with an unknown etiology. Several studies have been performed on the role of tumor necrosis factor-alpha (TNF-α) in RAS. The main purpose of this paper was to review TNF-α level and its gene polymorphism in patients with RAS, the factors influencing the production of TNF-α, a...

RATIONALE Tumor necrosis factor-alpha (TNF-α) is a potent pro-inflammatory mediator and its expression is up-regulated in chronic obstructive pulmonary disease (COPD). Tristetraprolin (TTP) is implicated in regulation of TNF-α expression; however, whether TTP is involved in cigarette smoke-induced TNF-α expression has not been determined. METHODS TTP expression was examined by western blot an...