OBJECTIVES Recent reports suggest efficacy of anti-tumour necrosis factor-alpha (TNF-α) therapy in Behçet's disease. However, the switching of anti-TNF-α agents for treatment failure remains unexplored. Our aims were to describe the efficacy and safety of a second anti-TNF-α agent in Behçet's disease patients after failure of a first agent. METHODS In this retrospective case series, 34 Behçet...

Tumor necrosis factor-α (TNF-α) is a pleiotropic cytokine. Since it reveals both proand anti-cancer properties (Balkwill et al., 2009), risk of malignancies in patients undergoing TNF-α antagonists therapy is always controversial. As our previous researches showed, breast cancer over-expressed TNF-α which played a vital role in the cancer’s occurrence and development, and we also found transmem...

Background: TNF-α and IL-6 are both pleiotropic cytokines playing major roles in cancer-associated cytokine networks. They have previously been investigated for their function in skin malignancies, mostly melanomas, and studies on NMSC patients are relatively fewer. In this study, we aimed to investigate the associations of serum levels of IL-6 and TNF-α with NMSCs and its clinicopathological f...

The aims of this study were to assess the risk of tuberculosis (TB) and the status of latent tuberculosis infection (LTBI) in Korean patients with inflammatory bowel disease (IBD) receiving tumor necrosis factor (TNF)-α blockers. We reviewed medical records of 525 Korean IBD patients (365 TNF-α blocker naïve and 160 TNF-α blocker exposed) between January 2001 and December 2013. The crude incide...

Tumor necrosis factor (TNF)-α, has been implicated in several muscle wasting disorders with increased levels of the cytokine reported in malnourished children. The role of TNF-α in mediating malnutrition-induced inhibition of diaphragm (DIA) muscle growth in young growing rats was evaluated. Three groups of rats were studied: 1) Control (CTL); 2) Nutritional deprivation (ND; 50% of normal food ...

Adipocyte tissue inflammation orchestrates the occurrence and development of diseases induced by obesity. Here, effects Lagerstroemia speciosa (L.) Pers total flavonoids (LTF) on TNF-α-induced insulin resistance (IR) inflammatory response in 3T3-L1 adipocytes underlying mechanisms were studied. Cell glucose uptake test confirmed that TNF-α could induce IR adipocytes. The sensitivity to was incr...