The effects of low Ca(2+) on ion currents in hen ovarian granulosa cells were examined. A fast activating and inactivating transient outward current (TOC) and a slowly activating outward current (SOC) could be observed. In the presence of normal Ca(2+) concentration (2. 5 mM) and with a holding potential of -80 mV, SOC was activated in all cells with command pulses more positive than -20 mV. In...

Pluronic F127 (F127), an amphiphilic triblock copolymer, has been shown to have significant potential for drug delivery, as it is able to incorporate hydrophobic drugs and self-assemble into nanosize micelles. However, it suffers from dissociation upon dilution owing to the relatively high critical micelle concentration and lack of stimuli-responsive behavior. Here, we synthesized the α-tocophe...

OBJECTIVE To introduce pharmacists to the process, challenges, and opportunities of creating transitions of care (TOC) models in the inpatient, ambulatory, and community practice settings. METHODS TOC literature and resources were obtained through searching PubMed, Ovid, and GoogleScholar. The pharmacist clinicians, who are the authors in this manuscript are reporting their experiences in the...

Titer on Chip (Flu-ToC) is a new technique for quantification of influenza hemagglutinin (HA) concentration. In order to evaluate the potential of this new technique, a comparison of Flu-ToC to more conventional methods was conducted using recombinant HA produced in a baculovirus expression system as a test case. Samples from current vaccine strains were collected from four different steps in t...

Activity-based costing (ABC) and the theory of constraints (TOC) represent alternative paradigms for evaluating the economic consequences of production-related decisions. However, their application can lead to contradictory productmix decisions. To resolve this con#ict, it is frequently suggested that the TOC is appropriate for the short run, while ABC is appropriate for the longer term. This p...

We used the Sacramento-San Joaquin River Delta CA (Delta, hereafter) as a model system for understanding how human activities influence the delivery of sediment and total organic carbon (TOC) over the past 50-60 years. Sediment cores were collected from sites within the Delta representing the Sacramento River (SAC), the San Joaquin River (SJR), and Franks Tract (FT), a flooded agricultural trac...

We used coupled watershed and reservoir models to evaluate the impacts of deforestation and l Niño Southern Oscillation (ENSO) phase on drinking water quality. Source water total organic carbon (TOC) is especially important due to the potential for production of carcinogenic disinfection byproducts (DBPs). The Environmental Fluid Dynamics Code (EFDC) reservoir model is used to evaluate the diff...

The Mollisols from the Pampas Region of Argentina have been described as presenting different compactability behaviors under agricultural systems. The purpose of this study was to provide information on the inherent soil factors related to the susceptibility to compaction. Total organic carbon (TOC), texture (CLAY, SILT, SAND), water retention at 0.33 kPa (WR), Proctor maximum bulk density (BDM...

This paper aims to introduce System Dynamics (SD) in applying Drum Buffer Rope (DBR) methodology of Theory of Constraints (TOC) in a three-stage flow shop system that produces a single product. To the best of our knowledge, although there are a lot of TOC applications using discrete simulation in production scheduling with DBR methodology, there are not any TOC application of DBR methodology in...

We evaluated the effects of alpha-Toc on surface expression of CD11b/CD18 on polymorphonuclear leukocytes (PMN) stimulated with N-formyl-methionyl-leucyl-phenylalanine (fMLP) and oxidized low-density lipoprotein (oxLDL). Incubation of PMN with fMLP (1 microM) or oxLDL (100 microg/mL) increased CD11b/CD18 expression; pretreatment with alpha-Toc reduced in a dose-dependent manner. PMN obtained fr...