Abstract Calmodulin-binding transcription activator 1 (CAMTA1) is a factor located on chromosome 1p, and we have recently reported that CAMTA1 expression reduced neurosphere formation tumor growth in nude mice, suggesting can function as suppressor experimental glioma. In the present study, investigated molecular network of CAMTA-1 glioma cells. We established cell lines with doxycycline-induci...

Abstract Background Breast cancer 2, early onset ( BRCA2 ) is a tumor suppressor gene. The protein encoded by this gene plays an important role in homologous recombination (HR)-mediated DNA repair. Deleterious mutations and downregulation of its expression have been associated with tumorigenesis dogs humans. Thus, regulation level for maintaining homeostasis recombination. Results In study, the...

The posttransplantation lymphoproliferative disorders (PT-LPDs) are a morphologically heterogeneous group of Epstein-Barr virus (EBV)-driven lymphoid proliferations of varying clonal composition. Some PT-LPDs regress after a reduction in immunosuppression, while others progress in spite of aggressive therapy. Previously defined morphologic categories do not correlate with clonality, and neither...

We previously reported frequent loss of heterozygosity on chromosome 9p in esophageal carcinomas and suggested that a tumor suppressor gene located on this chromosomal arm might be involved in development of these cancers. Since recently published studies have shown that a gene mapped on chromosome 9p21, MTS1/CDK4I (multiple tumor suppressor 1/cyclin-dependent kinase 4 inhibitor), is frequently...

background: the hbv-x (hbx) protein is believed to contribute to the development of hcc. however, the molecular mechanisms involved in hbx-mediated hepatocarcinogenesis remain obscure. in this study, the effect of hepatitis b virus x gene and its protein product hbxag on expression of p53 gene in hep g2 cell line was investigated. methods: viral dna extracted from hbv-positive serum and hbx gen...

The nuclear envelope separates and protects DNA from the cytoplasm. In cancer cells, frequent morphological abnormalities transient rupture of membrane promote damage malignancy. However, instability, acting as a tumor-promotion factor, can be viewed fatal weakness cells. Although exact mechanism is not clear, it known that loss tumor suppressor gene TP53 involved in instability this study, we ...

We previously reported the identification of TUSC1 (Tumor Suppressor Candidate 1), as a novel intronless gene isolated from a region of homozygous deletion at D9S126 on chromosome 9p in human lung cancer. In this study, we examine the differential expression of TUSC1 in human lung cancer cell lines by western blot and in a primary human lung cancer tissue microarray by immunohistochemical analy...