introduction : brooke-spiegler syndrome (bss) is a rare autosomal dominant disease characterized by the development of multiple adnexal cutaneous tumors such as cylindromas, trichoepitheliomas and spiradenomas. case description: a 49 years old female patient presented with a history of gradual appearance of multiple nodules situated predominantly on the scalp and face. pathologic examination of...

Abstract The Wilms' tumor 1 (WT1) gene is well known as a chameleon gene. It plays role suppressor in but also acts an oncogene other cancers. Previously, our group reported that canonical AUG starting site for the WT1 protein (augWT1) suppressor, whereas CUG (cugWT1) functions oncogene. In this study, we report oncogenic of cugWT1 AOM/DSS-induced colon cancer mouse model and urethane-induced l...

The Retinoblastoma 1 (RB1) gene, located on chromosome 13q14 and encodes the tumor-suppressor retinoblastoma protein, is cause of Retinoblastoma. mutational inactivation both gene alleles brings this cancer. (RB) high-risk histopathological characteristics indicate metastasis or local recurrence with rapid progresses following RB1 inactivation. There growing interest in regulatory activities un...

Mitotic recombination or nondysjunction are common mechanisms for tumor-specific loss of constitutional heterozygosity (LOH) and tumor suppressor allelic inactivation and can be useful in localizing new putative tumor suppressor genes. In osteosarcoma, the highest frequencies of LOll have been reported for chromosomes 3q, 13q, lip, and lSq. The high incidenceof LOll on chromosome3q suggeststhe ...

Background: Melanoma progression and metastasis is suggested to be mediated by increased accumulation of myeloid derived suppressor cells. Various chemotherapeutic drugs such as 5-Fluorouracil in single low concentration have the capacity, at least in part, to reverse tumor progression by reducing myeloid derived suppressor cellsmediated immunosuppression. Objective: To assess whether multiple ...

background there is evidence of a possible etiological role of human papillomaviruses (hpvs) in the development of colorectal cancer. loss of p53 tumor suppressor gene function has been found in many malignancies and it can occur in a variety of ways, including gene mutation and interaction with the e6 protein of oncogenic hpvs. the objective of this study was to determine the prevalence of hpv...