We show that HTLV-1 negative leukemia cells are more sensitive to TQ due to higher levels of drug-induced reactive oxygen species (ROS). PreG1 population in HTLV-1 negative Jurkat and CEM was higher than HTLV-1 transformed HuT-102 and MT-2 cells. Peripheral blood mononuclear cells were more resistant. Hoechst staining indicated more features of apoptosis, namely nuclear blebs and shrunken nucle...

OBJECTIVE To investigate the effects of thymoquinone (TQ) in a penicillin-induced epilepsy model in rats. METHODS This experimental study included 56 adult male Wistar rats. Experiments were performed in the Research Laboratory of the Department of Physiology, Medical School, Duzce University, Duzce, Turkey, between October 2013 and December 2014. Animals were divided into the following 7 gro...

BACKGROUND Development of new tinnitus treatments requires prospective placebo-controlled randomized trials to prove their efficacy. The Tinnitus Questionnaire (TQ) is a validated and commonly used instrument for assessment of tinnitus severity and has been used in many clinical studies. Defining the Minimal Clinically Important Difference (MCID) for TQ changes is an important step to a better ...

Objective: The in-vivo study was carried out to explore the possible protective effect of thymoquinone on chlorpromazine induced catalepsy and locomotor activity in rats. Materials and Methods: Twenty four rats were used for this study and were divided into four groups, each group containing six animals. The animals were evaluated after repeated administration of chlorpromazine (CPZ) 30 minutes...

BACKGROUND Toxic effects of anti-cancer and other drugs on the normal tissues could be reduced by the herbal plants and their fractions. This study investigated the protective effect of thymoquinone (TQ) as a fraction of Nigella sativa on methotrexate (MTX)- induced germ cell apoptosis in male mice. MATERIALS AND METHODS In this experimental study, thirty male Balb/c mice were divided randoml...

Pancreatic cancer is one of the most lethal cancers in the world, as it continues to be resistant to any therapeutic approaches. The high molecular weight glycoprotein mucin 4 (MUC4) is aberrantly expressed in pancreatic cancer and contributes to the regulation of differentiation, proliferation, metastasis, and the chemoresistance of pancreatic cancer cells. The absence of its expression in the...

objective(s): for determining the mechanism of anti-asthmatic effect of thymoquinone, this investigation evaluated the effect of thymoquinone in the presence of selective a2a and a2b adenosine receptor antagonists (zm241385 and mrs1706, respectively). materials and methods: seventy guinea pigs were randomly divided to 7 groups; control (c), sensitized with ovalbumin (s), sensitized groups pretr...

We present a new proof of the irrationality of values of the series Tq(z) = ∑∞ n=0 z nq−n(n−1)/2 in both qualitative and quantitative forms. The proof is based on a hypergeometric construction of rational approximations to Tq(z).

Binding interactions between twisted cucurbit[14]uril (tQ[14]) and a series of alkyldiammonium ions both in aqueous solution and DMSO media were investigated by NMR spectroscopy and ITC. Experimental data indicate that tQ[14] possesses two kinds of cavities with different space environments, which can encapsulate two or even three guest molecules with suitable shape and size.

Abstract Oil from Nigella sativa seeds (“black seed oil”) has been used for health care and medical purposes over 2000 years. The major active compound thymoquinone (TQ) shown to have immune regulatory effects in various diseases. Tumor microenvironment is critical tumor development. Immune cells, particularly T are central players kill cells affect progression metastasis. impact of TQ on human...