In this study, a novel method is described for the determination of tramadol in biological fluids using molecularly imprinted solid-phase extraction (MISPE) as the sample clean-up technique combined with high-performance liquid chromatography (HPLC). The water-compatible molecularly imprinted polymers (MIPs) were prepared using methacrylic acid as functional monomer, ethylene glycol dimethacryl...

The hypothesis that repeated measurements during 4 subsequent days affect withdrawal latencies in Hargreaves test was investigated. Paw withdrawal latencies to radiant heat were determined in the control, tramadol or saline group of male Wistar rats. The control group (N=10) had no treatment. Tramadol group (N=7) and saline group (N=7) received one daily intraperitoneal injection of tramadol (1...

OBJECTIVE To compare the costs of treating osteoarthritis (OA) pain using combination tramadol/paracetamol tablets, Non-Steroidal Anti-Inflammatory Agents (NSAID) alone or NSAID plus proton pump inhibitors (PPI) from the perspective of the Spanish National Health System. METHODS A decision-analytical model was constructed to analyze the cost associated with three treatment strategies over 6 m...

OBJECTIVES To assess ECG changes in patients with tramadol-induced seizure(s) and compare these changes in lower and higher than 500 mg tramadol doses as a main goal. MATERIAL AND METHODS In an analytical-cross sectional manner over 1 year, 170 patients with idiosyncratic seizure(s) after using tramadol, were studied. Full data were recorded for each patient. ECGs were taken from all the pati...

BACKGROUND Intra-articular analgesia is a pain reliever that is frequently administered following arthroscopic knee surgery. OBJECTIVES The purpose of this study was to compare the efficacy of intra-articular application of morphine and tramadol on postoperative pain after arthroscopic knee surgery. PATIENTS AND METHODS For this randomized double blinded clinical trial, 132 patients undergo...

Nous rapportons Huit cas de crises convulsives diagnostiquées comme maladie épileptique après ingestion de Tramadol et d’autres substances psychotropes dont la Caféine dans une région ou maladie épileptique et addiction au café sont fréquentes. L’objectif de ce travail était d’informer les praticiens sur le risque de convulsion lié à la consommation du Tramadol seul ou en association avec d’aut...

Cardiovascular effects of tramadol were evaluated in dogs anesthetized with sevoflurane. Six beagle dogs were anesthetized twice at 7 days interval. The minimum alveolar concentration (MAC) of sevoflurane was earlier determined in each dog. The dogs were then anesthetized with sevoflurane at 1.3 times of predetermined individual MAC and cardiovascular parameters were evaluated before (baseline)...

Introduction: Motor behavior and coordination impairment are known side effects of opioid treatment, yet very few studies have investigated the effects of tramadol on motor behavior, or compared its effect with the effect of an opioid. This study investigates the effects of chronic injection of morphine and tramadol on rat motor function during infancy. Methods: Neonate rats (n=56) were randoml...

We tested the effect of tramadol on ventilatory control by quantifying its effect on the steady-state ventilatory carbon dioxide response and by locating its site of respiratory action within the ventilatory control system. We imposed square-wave changes in end-tidal carbon dioxide (approximately 1 kPa; end-tidal oxygen concentration kept constant at resting levels) in 10 healthy volunteers (si...