AIMS Co-crystal of tramadol-celecoxib (CTC) is a novel co-crystal molecule containing two active pharmaceutical ingredients under development by Esteve (E-58425) and Mundipharma Research (MR308). This Phase I study compared single-dose pharmacokinetics (PK) of CTC with those of the individual reference products [immediate-release (IR) tramadol and celecoxib] alone and in open combination. MET...

Tramadol® (analgesic of the landing 2) is a centrally acting analgesic with a dual mode of action. Its analgesic efficacy is attributed to its partial affinity for the (μ) mu-opiate receptor and its inhibition of noradrenaline and serotonin reuptake. Acting in a synergistic manner and being more efficacious, Tramadol® is used worldwide for the treatment of moderate to severe acute or chronic pa...

The appearance of a new product on the pharmaceutical market, especially an antidepressant, may lead in the near future to abuse or use in suicide attempts. A case of a complex poisoning of a middle-aged woman with tramadol and tianeptine is described. Tramadol and tianeptine were identified in the examined biological material. Tianeptine is the only drug in the dibenzothiazepine group that has...

In the present study a new alcohol derivative of tetrahydrogeraniol (THG), an acyclic monoterpene, has been prepared by using Grignard reagent and methyl cyclopropyl ketone. Penetration enhancing effects of THG and the synthesized derivative 5,9-dimethyl-2-cyclopropyl-2-decanol (DICNOL) on the transdermal penetration of 5-fluorouracil (5-FU) and tramadol hydrochloride (tramadol HCl) across the ...

An analysis of the treatment of nonmalignant pain in the elderly at a long-term facility was conducted to allow development of a pain management program that complies with both JCAHO guidelines for pain management and with the Tennessee Medicaid (TennCare) reimbursement schedule, and to determine if tramadol can meet the standards of pain management under these new guidelines. Inclusion criteri...

The development of combination therapy is a coherent approach in severe pain treatment. The present study investigated the antinociceptive effect of pregabalin alone and in combination with tramadol in acute pain modeling. Therefore, three groups of male mice received either pregabalin (1 to 400 mg/Kg), tramadol (10 to 80 mg/Kg) or their combination intraperitoneally. Then latency time, maximum...

Background: Patient-controlled analgesia (PCA) has been advocated as superior to conventional controlled analgesia with less risk to patients in cardiac surgery. In this double-blinded, randomized controlled trial, we tested whether the addition of Tramadol to morphine for patient-controlled analgesia (PCA) resulted in improved analgesia efficacy and smaller morphine requirements compared with ...

BACKGROUND Tramadol has been administered peripherally to prolong analgesia after brachial plexus and neuraxial blocks. Our aim was to evaluate the systemic and perineural effects of tramadol as an analgesic adjunct to psoas compartment block (PCB) with levobupivacaine. METHODS In a randomized, prospective, double-blinded trial, 60 patients (ASA I-III), aged 49-88 yr, undergoing primary total...

RATIONALE During the past 30 years, myocardial ischemia/reperfusion injury in rodents became one of the most commonly used model in cardiovascular research. Appropriate pain-prevention appears critical since it may influence the outcome and the results obtained with this model. However, there are no proper guidelines for pain management in rats undergoing thoracic surgery. Accordingly, we evalu...