Abstract Tranexamic acid (TXA) is an inexpensive, commonly used antifibrinolytic agent that has been shown to significantly reduce perioperative blood loss and transfusion requirements after total hip knee replacement. We conducted a systematic review meta-analysis synthesise the latest evidence regarding effects of TXA on in shoulder replacement (TSR) elbow (TER). systematically searched MEDLI...

Background: The incidence of renal hemorrhage during percutaneous nephrolithotomy (PCNL) is high. We sought to evaluate the effects of tranexamic acid (TXA) on bleeding and hemoglobin levels of patients with staghorn calculi treated with PCNL.Methods: In a double-blind clinical trial, 120 patients with staghorn calculi candidated for PCNL in Alzahra Hospital between January 2014 and Novem...

BACKGROUND Postpartum haemorrhage (PPH) is the third-most common cause of maternal death in the United States and it is still the first prevalent cause of maternal death in developing countries. Active prevention of haemorrhage with an uterotonic or other new drugs leads to a decrease in postpartum vaginal haemorrhage. The aim of this study was to compare anti-haemorrhagic effect of Tranexamic ...

BACKGROUND To compare the efficacy and safety of the combined application of both intravenous and topical tranexamic acid (TXA) versus the single use of either application in patients with total knee and hip arthroplasty (TKA and THA). METHODS Potentially relevant studies were identified from electronic databases including Medline, PubMed, Embase, ScienceDirect, and the Cochrane Library. Rand...

Background: Tranexamic acid (TXA) reduces the risk of death and is recommended as a treatment for women with severe postpartum bleeding. There hope that giving TXA shortly before or immediately after birth could prevent Extending use to harmful bleeding improve outcomes millions women; however, we must carefully consider balance benefits potential harms. This article...

The purpose of this study was to retrospectively evaluate the efficacy a tranexamic acid (TXA) perioperative protocol for primary hip- and knee arthroplasty, in terms allogenic blood transfusion rates. A retrospective cohort conducted included all hip arthroplasty procedures period 2014-2019. Patients who underwent surgery due trauma or revision were excluded. total amount 5205 patients eligibl...

Abstract Purpose Elderly patients with intertrochanteric fractures exhibit post-traumatic hidden blood loss (HBL). This study aimed to evaluate the efficacy and safety of reducing HBL via early intravenous (IV) tranexamic acid (TXA) intervention in elderly fracture. Methods A prospective randomized controlled was conducted 125 (age ≥ 65 years, injury time ≤ 6 h) who presented fracture from Sept...

BACKGROUND Early administration of tranexamic acid (TXA) has been associated with a reduction in mortality and blood product requirements in severely injured adults. It has also shown significantly reduced blood loss and transfusion requirements in major elective pediatric surgery, but no published data have examined the use of TXA in pediatric trauma. METHODS This is a retrospective review o...

BackgroundHematoma formation and the need for blood transfusions are commonly reported complications after shoulder arthroplasty. Tranexamic acid (TXA) has been widely used in hip knee arthroplasty to decrease perioperative loss. The role of TXA is still being established arthroplasty.Materials methodsWe conducted a double-blind randomized controlled trial comparing intravenous vs. placebo 60 p...