Background: Tranexamic acid (TXA) is effective in reduction of blood loss after major surgical procedures. In TKA surgeries, it commonly administered intravenously. Since there are contraindications systemic use TXA, local/intraarticular TXA can also be used. The efficacy both and local administration demonstrated the literature. aim was to assess effect intraarticular during total knee arthrop...

Introduction: Tranexamic acid (TXA) is routinely used during cardiac surgical procedures involving cardiopulmonary bypass (CPB) in order to reduce blood loss [1]. Although the optimum dose of TXA has been a subject of debate, a dosing regimen also sometimes referred to as the BART dose remains a popular choice for high-risk cardiac surgery [2]. The pharmacokinetics of TXA during the perioperati...

Antifibrinolytic drugs are widely used to reduce blood loss during surgery. One serious adverse effect of these drugs is convulsive seizures; however, the mechanisms underlying such seizures remain poorly understood. The antifibrinolytic drugs tranexamic acid (TXA) and ε-aminocaproic acid (EACA) are structurally similar to the inhibitory neurotransmitter glycine. Since reduced function of glyci...

Tranexamic acid (TXA) is an antifibrinolytic agent widely used to reduce blood loss during surgery. However, a serious adverse effect of TXA is seizure due to inhibition of γ-aminobutyric acid (GABA) and glycine receptors in cortical neurons. These receptors are also present in the spinal cord, and antagonism of these receptors in spinal dorsal horn neurons produces pain-related phenomena, such...

background:  tranexamic acid (txa) has received extensive attention in management of blood loss in orthopedic surgeries. however, the ideal method of txa administration is still controversial. this study aims to determine whether intraarticular injection of txa reduces blood loss after total knee arthroplasty (tka).   methods:  through a retrospective case-control study consecutive tka patients...

BACKGROUND Total knee arthroplasty (TKA) is gradually regarded as an effective choice for end-stage osteoarthritis or rheumatic arthritis. In the past, the management of tranexamic acid (TXA) using intravenous injection or topical application has been extensively researched. However, several studies have reported that oral TXA has an effect on blood loss. Therefore, a meta-analysis should be pe...

Objective: To compare patients who received preoperative intravenous (IV) plus postoperative maintenance IV tranexamic acid (TXA) therapy and perioperative periarticular TXA to those did not receive during total knee arthroplasty (TKA) in terms of blood loss, transfusion requirements, length hospital stay.
 Material Method: Data from 194 underwent TKA between 2016 2019 were reviewed. A 106...

introduction: traumatic brain injury is considered as the major cause of mortality and hospitalization of about ten million people across the globe. most of these patients are young and active people suffering disabilities. tranexamic acid (txa) therapy is commonly used to reduce blood loss and need for blood transfusions in surgical cases. this study aimed at investigating the effect of tranex...

Using kitchen scales, carefully weight out 4 kg of rice and pour it into a deep saucepan. Now put your hands into the rice and let the grains run between your fingers. Contemplate carefully each grain. The number of grains (about 140,000) is approximately the number of lives that could be saved each year world-wide if all hospitalized trauma patients with significant bleeding were treated with ...

Tranexamic acid (TXA) reduces blood loss by inhibiting the enzymatic breakdown of fibrin. It is often used in surgery to decrease bleeding and the need for blood transfusion. In 2011, results from a multi-center, randomized, and placebo-controlled trial (CRASH-2 trial) showed that TXA (1 g loading dose over 10 min followed by an infusion of 1 g over 8 h) safely reduces mortality in bleeding tra...