Antifungal activity of 2-hydroxy 4,4'6'trimethoxy chalcone individually was tested against spore germination of ten fungi of different genera. Efficacy of the chemical was also tested against conidial germination and other growth parameters of Erysiphe pisi on excised pea leaves. 2-Hydroxy 4,4'6'trimethoxy chalcone inhibited spore germination at all the concentrations. Maximum inhibition was ob...

A series of flavonoids 9a-f, 13b, 13d, 13e and 14a-f bearing diverse aliphatic amino moieties were designed, synthesized and evaluated for their cytotoxic activities against the ECA-109, A-549, HL-60, and PC-3 cancer cell lines. Most of the compounds exhibited moderate to good activities. The structure-activity relationships were studied, revealing that the chalcone skeleton is the most prefera...

3β-Azidocholest-5-ene (3) and (3β)-3-(prop-2-yn-1-yloxy)cholest-5-ene (10) were prepared as substrates to synthesize a variety of three-motif pharmacophoric conjugates through CuAAC. Basically, these conjugates included cholesterol and 1,2,3-triazole moieties, while the third, the pharmacophore, was either a chalcone, a lipophilic residue or a carbohydrate tag. These compounds were successfully...

The referenced article in PCCP presents calculations of solvent kinetic isotope effects that indicate the rate-limiting step base-catalyzed chalcone formation aqueous solution becomes second enolization.

Skin hyperpigmentation is a biological process that results in an excess production of melanin. Tyrosinase inhibition effective approach to this condition, although inhibitors reported the literature lack clinical efficacy or show toxic effects. Chalcone derivatives are well known tyrosinase but insoluble aqueous phase limiting its use final product formulations. The aim study develop new chalc...

Ultraviolet (UV) irradiation is a serious problem for skin health thus the interest in research to develop sunscreen agent has been increasing. Chalcone promising compound be developed as its chromophore absorbs UV region. Therefore, present work, we synthesized eight chalcone derivatives through Claisen–Schmidt condensation at room temperature. The evaluation of optical properties each region ...

Stigma is a crucial structure of female reproductive organ in plants. Stigma color is usually regarded as an important trait in variety identification in some species, but the molecular mechanism of stigma color formation remains elusive. Here, we characterized a tomato mutant, yellow stigma (ys), that shows yellow rather than typical green color in the stigma. Analysis of pigment contents reve...