signal transducers and activators of transcription (stats) are cytoplasmic transcription factors that have a key role in cell fate. stats, a protein family comprised of seven members, are proteins which are latent cytoplasmic transcription factors that convey signals from the cell surface to the nucleus through activation by cytokines and growth factors. the signaling pathways have diverse biol...

background and aims: the e2f family of transcription factors is encoded by at least eight genes, e2f1-8. these proteins are important targets of the retinoblastoma protein (rb) contributed in regulation of transcription, cell cycle and apoptosis. the aim of this study was to investigate the expression levels of e2f protein family including e2f1, e2f2, e2f7, e2f8 and rb1 in the lineage negative ...

background:the zinc-finger x linked (zfx) gene encodes a transcription factor that acts as a regulator of self-renewal of stem cells. due to the role of zfx in cell growth, understanding zfx protein-protein interactions helps to clarify its proper biological functions in signaling pathways. the aim of this study is to define zfx protein-protein interactions and the role of zfx in cell growth. m...

macrophages accumulate in poorly vascularised and hypoxic sites including solid tumours, wounds and sites of infection and inflammation where they can be exposed to low levels of oxygen for long periods. up to date, different studies have shown that a number of transcription factors are activated by hypoxia which in turn activate a broad array of mitogenic, pro-invasive, pro-angiogenic, and pro...