Atrial fibrillation (AF) is a prevalent cardiac arrhythmia with a significant genetic component. In recent years, familial and population-based genetic studies in AF have led to the emergence of transcription factors as potentially important contributors to arrhythmia susceptibility. Further evidence to implicate transcription factors in AF has come from studies in animal models, which demonstr...

Saleh A. and M. Pagés (2003): Plant AP2/ERF transcription factors. – Genetika, Vol. 35, No. 1, 37-50. Transcription factors (TFs) play important roles in plant development and its response to the biotic and abiotic stresses. AP2/ERF transcription factors family is unique to plants and a conserved AP2/ERF domain of about 60 amino acids characterized these transcription factors. AP2/ERF genes hav...

FOXM1 (12p13.33) GLI1, doxorubicin, NRAS, fulvestrant, butyric acid, FGF7, CDKN1A, YY1, MSA, vitamin D3, TNFSF11, IL6, CDC2 CDC25B, CENPA, AURKB, CCNA2, CCNF, CENPB, BIRC5, CCNB1, CDKN1A, ESR1, ADAM17, GLB1 Controls progression into S phase; regulates genes required for mitotic entry; liver development. Reduced hepatoblast and cardiomyocyte mitosis, ventricular hypoplasia. Die perinatally. Upre...

Many plant processes depend on differential gene expression, which is generally controlled by complex proteins called transcription factors (TFs). In peach, 1533 TFs have been identified, accounting for about 5.5% of the 27,852 protein-coding genes. These TFs are the reference for the rest of the Prunus species. TF studies in Prunus have been performed on the gene expression analysis of differe...

Background EBV2 is estimated to infect 90% ofthe world’s population and is by far the best example of a common human virus that efficiently immortalizes human cells. The principal target cells for EBV infection are human B-lymphocytes and oropharyngeal epithelial cells. The virus immortalizes B-lymphocytes and persists in those cells predominantly as a nonproductive, latent infection (reviewed ...

The Sp family of transcription factors binds GC-rich DNA sequences. The ubiquitously expressed Sp1 and Sp3 have been well characterized in mammals. Presented here is the characterization of the only Sp protein expressed in the liver or heart tissue of the teleost fish Fundulus heteroclitus. This protein, fSp3, is most similar to and homologous with mammalian Sp3 proteins. The evolution of the S...

Studies of the feedback regulation of cholesterol synthesis in animals have led to the identification of a unique family of membrane-bound transcription factors, sterol regulatory element binding proteins (SREBPs) (Brown and Goldstein, 1997). In the presence of cholesterol, SREBPs are sequestered in the endoplasmic reticulum (ER). In the absence of a sterol signal, however, SREBPs undergo speci...

Introduction Transcription factors are proteins that regulate gene expression levels by binding to specific short DNA sequences (cisacting elements) in the promoter region of target genes, and enhancing or repressing their transcription rate. Their identification is a key step for the reconstruction of transcriptional regulatory networks. The availability of complete genomes together with prote...