Although transdermal drug delivery has many potential advantages, the permeability of skin to macromolecules is extremely low. However, the application of short, high-voltage pulses to electroporate skin has recently been shown to make it reversibly permeable. A number of studies have demonstrated that electroporation-mediated transdermal delivery of peptides, polysaccharides, oligonucleotides ...

A dminMed is developing an innovative line of novel microneedle-based transdermal drug delivery devices. The current pipeline comprises an advanced microneedle arraybased pen-injector device (the AdminPen) that painlessly and conveniently injects therapeutic levels of standard liquid pharmaceutical drugs or cosmetic actives through the skin. This breakthrough technology revolutionizes the way i...

By definition, transdermal, drug-delivery applications mandate the use of adequate adhesive systems to not only keep the pharmaceutical agent in contact with the intended surface, but to facilitate sustained, controlled delivery. Engineers who must determine which silicone chemistry is optimal for their device have a few options. While pressuresensitive silicone adhesives (PSAs) have typically ...

Oestrogen transdermal patches are now being used in the prophylaxis and treatment of post partum depression. Oestrogens are known to have potential adverse effects on breastfed infants. This case describes jaundice and poor weight gain in the child of a lactating mother prescribed oestrogen transdermal patches. There is a need for caution in the use of this therapy in breast feeding mothers and...

Transdermal drug delivery is a validated technology contributing significantly to global pharmaceutical care. Since 1980, impressive growth in this field has been observed with many commercial successes; importantly, a new chemical entity was recently developed and approved for transdermal administration without having first been given as an injectable or oral dosage form. The progress achieved...

TThis paper investigates the effect that body weight and gender have on the transdermal transport of ethanol observed after the ingestion of an alcohol beverage. The approach is to use a computational model which combines a multi-compartment ethanol metabolism model with a transdermal transport model. Males have a larger proportion of alcohol soluble body mass when compared to females of the sa...

Transdermal therapeutic systems (TTS) containing captopril were developed by using synthetic and pH independent polymers, Eudragit RL 100 and RS 100. The formulations were characterized in terms of their appearance, thickness, captopril content, in vitro release rate and diffusion profiles. In vitro release studies demonstrated controlled release for each formulation developed. In viro and ex v...

Microneedle-mediated Transdermal and Intradermal Drug Delivery covers the major aspects relating to the use of microneedle arrays in enhancing drug delivery applications. It provides an overview of the various methods employed to design and produce microneedles, from the different materials involved to the importance of application methods. It carefully and critically reviews ongoing transderma...

Microneedle-mediated Transdermal and Intradermal Drug Delivery covers the major aspects relating to the use of microneedle arrays in enhancing drug delivery applications. It provides an overview of the various methods employed to design and produce microneedles, from the different materials involved to the importance of application methods. It carefully and critically reviews ongoing transderma...

Transdermal drug delivery systems have been around for decades, and current technologies (e.g., patches, ointments, and creams) enhance the skin permeation of low molecular weight, lipophilic drugs that are efficacious at low doses. The objective of current transdermal drug delivery research is to discover ways to enhance skin penetration of larger, hydrophilic drugs and macromolecules for dise...