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...................................................................................................... 12 ABBREVIATIONS............................................................................................. 18 GENERAL INTRODUCTION............................................................................. 20 CLASSICAL VIEW OF ASTROCYTES IN BRAIN FUNCTION ....................................

Fibrosis is a scarring process that is a common feature of chronic organ injury. It is characterized by elevated activity of transforming growth factor-beta resulting in increased and altered deposition of extracellular matrix and other fibrosis-associated proteins. Recent work has demonstrated that bone morphogenetic protein-7 blocks transforming growth factor-beta signaling. Moreover, member ...

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