نتایج جستجو برای: transforming growth factor beta (tgf beta)

تعداد نتایج: 1637919  

Journal: :iranian biomedical journal 0
جلیل توکل افشاری jalil tavakkol afshari trine n jorgensen ian v hutchinson ian v hutchinson trine n jorgensen richard a kay

transforming growth factor beta (tgf-b) is a mediator released by nearly all cell types. it has suppression activity on the immune system, but exactly how this effect is carried out is not clear. previous experiments showed that igg interacts with or carriers active tgf-b, that could suppresses cytotoxic t-cell responses to an immunogenic tumor in mice. since t cell receptor (tcr) has structura...

Introduction: Systemic lupus erythematosus (SLE) is a chronic systemic inflammatory autoimmune disease characterized by a breakdown of self-tolerance. Transforming growth factor-β1 is a cytokine produced by both immune and non immune cells, and it has a wide operating range. human TGF-β1 gene is located on chromosome 19q13 . The aim of this study was investigating the TGF-β1 Gene...

Journal: :The Journal of Japan Atherosclerosis Society 1996

Journal: :anatomical sciences journal 0
sina bozorgmehr azita parvaneh tafreshi shahsanam abbasi bahman zeynali

introduction: astrocytes, the most abundant glia in the central nervous system, modulate neuronal survival and function. astrocytic functions are mediated by synthesis and secretion of wide ranges of polypeptides through mechanism (s) poorly understood. among these, tgfβs are synthesized and released by the astrocytes. in this study, the involvement of wnt signaling pathway on the synthesis of ...

Journal: :genetics in the 3rd millennium 0
mohammad hossein mohammadi naser amirizadeh mehdi allahbakhshian farsani hamideh aghaee nezhad ahmad ahmadzadeh safa najafi

acute myeloblastic leukemia is the most frequent cancer in adults and the patients have a wide range of sub-classes. hla dr negative cases represent one of the major immune-phenotypic classes.  hla-dr is routinely used to distinguish acute promyelocytic leukemia (apl) from other aml subclasses based on the immunophenotype. the tgf-b signaling pathway, as a critical regulator, guides different v...

Journal: :current medical mycology 0
alireza izadi dept. of medical mycology, faculty of medicine golamreza asadikaram dept. of biochemistry, faculty of medicine nozar nakhaee dept. of epidemiology, faculty of medicine sanaz hadizadeh dept. of medical mycology, faculty of medicine seyyed amin ayatollahi mousavi dept. of medical mycology, faculty of medicine

background and purpose: tgf-β is a potent regulator and suppressor of the immune system and overproduction of this cytokine may contribute to immunosuppression in hiv-infected patients. increasing population of immunosuppressed patients has resulted in increasingly frequent of fungal infections, including oral candidiasis. the aim of this study was to evaluate the plasma levels of tgf-β under i...

Asili, Javad , Baharara, Javad , Kerachian, Mohammad Amin , Parivar, Kazem , Soltani, Mozhgan ,

Background: Marine natural products contain a wide range of bioactive compounds with therapeutic properties that have revealed crucial properties in the treatment of some diseases. Some of these compounds have recently received considerable attention for drug discovery. In this study we examined the anti-angiogenic effect of saponin isolated from Holothuria leucospilota (sea cucumber) through e...

ژورنال: Anatomical Sciences Journal 2011
Ali Abbasi Moghaddam, Mohammad Ali, Alizadeh, Akram, Katebi, Majid, Zamani , Mohammad , Mehdizadeh, Mahdi, Panahzadeh, Hassan Ali, Solimani , Mansoureh,

Purpose: Effects of TGF-b and b-FGF on the Potential of Peripheral Blood-Borne Stem Cells and Bone Marrow-Derived Stem Cells In Wound Healing in a Murine Model.Materials and Methods: Peripheral blood mesenchymal stem cells (PBMSCs) and bone marrow stem cells (BMSCs) cultured in media with transforming growth factor-beta (TGF-b) and basic fibroblast growth factor (b-FGF). Stem cells labeled with...

Journal: :jundishapur journal of microbiology 0
seyed hossein abdollahi molecular medicine research center, rafsanjan university of medical sciences, rafsanjan, ir iran fateme ayoobi physiology and pharmacology research center, rafsanjan university of medical sciences, rafsanjan, ir iran hossein khorramdelazad molecular medicine research center, rafsanjan university of medical sciences, rafsanjan, ir iran behzad nasiri ahmadabadi immunology of infectious diseases research center, rafsanjan university of medical sciences, rafsanjan, ir iran mohammadtaghi rezayati immunology of infectious diseases research center, rafsanjan university of medical sciences, rafsanjan, ir iran mohammad kazemi arababadi immunology of infectious diseases research center, rafsanjan university of medical sciences, rafsanjan, ir iran

conclusions based on our study, in vivo prepared e/sa may be considered as a good candidate for animal immunization. results our results showed that the serum levels of anti-e/sa immunoglobulins significantly increased in all of the immunized groups. the differences of the serum levels of tgf-β between the groups were statistically significant at days 28 and 56 after immunization with e/sa. bac...

Journal: :reports of biochemistry and molecular biology 0
mohammad reza khakzad tel: +98 9151176352; fax: +98 51- 32250048 farhad salari immunology research center, medical school, mashhad university of medical sciences, mashhad, iran maryam javanbakht department of psychiatrics, islamic azad university, mashhad branch, mashhad, iran maryam hojati noor hedayat center of autism spectrum disorders, mashhad, iran abdolreza varasteh allergy research center, mashhad university of medical sciences, mashhad, iran mojtaba sankian immunology research center, medical school, mashhad university of medical sciences, mashhad, iran

background: transforming growth factor-β1 (tgf-β1) has been found to play a crucial role in early central nervous system development. several studies have illustrated decreased tgf-β1 levels in sera and brains of autistic children. two point mutations in the tgf-β1 signal peptide at 869t/c and 915g/c have been reported to influence tgf-β1 expression. the aim of the present study was to investig...

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