BAFF is an important prosurvival cytokine for mature B cells. However, previous studies have shown that BAFFR is already expressed at the immature B cell stage, and that the prosurvival protein Bcl-2 does not completely complement the B cell defects resulting from the absence of BAFFR or BAFF. Thus, we hypothesized that BAFF also functions to aid the differentiation of nonautoreactive immature ...

My research plan for the next few years and for the next decade is to extend my current research to answers the broad questions: (1) How do disks evolve and form planetary systems? (2) What is the origin of life? We have been taking advantage of the Spitzer Space Telescope to reveal various stages of star formation and evolution of protoplanetary disks. One of our major achievements with Spitze...

In this study, we examined characteristics associated with experiencing persistent and transitional adult food insecurity and how persistent and transitional adult food insecurity influences toddler cognitive and motor development, along with toddler's weight and health status. Using the first 2 waves of the Early Childhood Longitudinal Study-Birth Cohort, 4 mutually exclusive variables capturi...

OBJECTIVE To assess the provisions made for the transfer of adolescents with juvenile idiopathic arthritis to adult rheumatology clinics in the UK and the impact of a transitional care programme. METHODS An audit of the documentation of the provisions made for transfer in 10 centres participating in a controlled trial of transitional care. Each centre conducted a retrospective case note audit...

Epithelial tumors are rarely seen during the first two decades of life. We report a 17 year old male with primary transitional cell carcinoma (TCC) of the bladder.

PURPOSE Effective transitional care is needed to improve the quality of life in older adult patients with chronic illness and avoid discontinuity of care and adverse events. The aim of this article is to provide an overview of the key features, broader implications, and the utility of Meleis' transition theory intended for the transitional care of older adults with chronic illnesses. We present...

BACKGROUND The anatomic-electrophysiological correlation of AV nodal reentry is unclear. To localize reentrant circuits during atrial and ventricular echoes and to characterize sites of slow conduction and block, we correlated histology with electrophysiology of the AV node. METHODS AND RESULTS In 10 isolated dog hearts, extracellular electrical activity was recorded in Koch's triangle at 208...

The aim of this work is to simulate rare ed gas ow in complex geometries, under ow conditions that range from the hydrodynamic, through the transitional, to the molecular regimes. Existing computational models apply to molecular or viscous ow, but the treatment of the transitional ow is still underdeveloped. To deal with the di cult transitional ow, two models with overlapping ranges of applica...

In this report, we describe the identification and characterization of an early embryoid body-derived colony, termed the transitional colony, which contains cell populations undergoing the commitment of mesoderm to the hematopoietic and endothelial lineages. Analysis of individual transitional colonies indicated that they express Brachyury as well as flk-1, SCL/tal-1, GATA-1, (beta)H1 and (beta...

Ligation of B cell receptors on immature bone marrow B cells, either by an endogenous Ag or by an anti-B cell receptor Ab induces secondary V(D)J gene rearrangements, termed receptor editing. Whether the same signal induces receptor editing in transitional B cells is not clear. In this study, we examined the responses of immature and transitional B cells from V(H)12Vkappa1A Ig transgenic mice t...