Conceptual knowledge is closely related to a deeper understanding of existing facts and relationships, but also to the argumentation and communication of why something happens in a particular way. Formal Concept Analysis (FCA) is the core of Conceptual Knowledge Processing. It emerged from applied mathematics and quickly developed into a powerful framework for knowledge representation. It is ba...

Human colon cancers commonly harbor loss of function mutations in APC, a repressor of the canonical WNT pathway, thus leading to hyperactive WNT-TCF signaling. Re-establishment of Apc function in mice, engineered to conditionally repress Apc through RNAi, resolve the intestinal tumors formed due to hyperactivated Wnt-Tcf signaling. These and other results have prompted the search for specific W...

Constitutive activation of canonical WNT-TCF signaling is implicated in multiple diseases, including intestine and lung cancers, but there are no WNT-TCF antagonists in clinical use. We have performed a repositioning screen for WNT-TCF response blockers aiming to recapitulate the genetic blockade afforded by dominant-negative TCF. We report that Ivermectin inhibits the expression of WNT-TCF tar...

Specific recognition of DNA by transcription factors is essential for precise gene regulation. In Wingless (Wg) signaling in Drosophila, target gene regulation is controlled by T cell factor (TCF), which binds to specific DNA sequences through a high mobility group (HMG) domain. However, there is considerable variability in TCF binding sites, raising the possibility that they are not sufficient...

Multidisciplinary, interdisciplinary, and transdisciplinary collaboration (TDC) continue to address complex societal problems such as sustainable development, global environmental change, public health challenges. Nature-based design (NBD) methods including biomimicry, biomorphism, biophilia, bio-utilization zoomorphism are essential for the of built environment (SBE). Currently, there is no fr...

Triadic concept graphs have been introduced as a mathema-tization of conceptual graphs with subdivision. In this paper it is shown that triadic concept graphs of a triadic power context family always form a complete lattice with respect to the generalization order. For stating this result, a clariication of the notion of generalization is needed. It turns out that the generalization order may b...

TCF transcription factors are mediators of the WNT signaling pathway and are antagonized by the transforming growth factor beta signaling pathway. Here human TCF-3 has been cloned and characterized. Differential expression analyses of TCF genes in gastric cancer revealed that TCF-1 was expressed in most cases of primary gastric cancer at almost the same level as in normal gastric mucosa and tha...