Rh(II)-catalyzed novel tandem intramolecular cycloisomerizations of aldehydes or ketones with 1-sulfonyl 1,2,3-triazoles have been disclosed, providing a facile protocol to access a series of functionalized aza-bridged benzodioxepine heterocycles.

Galactosides and lactosides bearing triazoles or isoxazoles, regiospecifically prepared by [1,3]-dipolar cycloadditions between alkynes, azides or nitrile oxides, provided specific galectin-1 and -3 inhibitors with potencies as low as 20 microM.

This communication presents the synthesis of a novel photolabile azidolinker based on the o-nitroveratryl group. The application of this linker for the synthesis and photolytic release of NH-1,2,3-triazoles is described.

A novel magnetically recoverable and recyclable nanocatalyst, Cu 2 O-Fe 3 O 4 @TNT, has been developed for the synthesis of 1,4-disubstituted 1,2,3-triazoles at room temperature in aqueous medium.

Immobilised [Cu(NHC)] catalysts are reported for the preparation of 1,2,3-triazoles. In addition to showing outstanding catalytic activity, the catalyst systems are easy to prepare and can be recycled many times.

A 1,3-dipolar cycloaddition reaction taking place quantitatively between propiolic acid "guests" and azide functions previously attached to binding sites within the cavity of a {Mo(132)}-type Keplerate reproducibly gives a 2 : 1 ratio of 1,4- and 1,5-triazoles.

A supported gold nanoparticle-catalyzed strategy has been utilized to promote a click chemistry reaction for the synthesis of 1,2,3-triazoles via azide-alkyne cycloaddition (AAC) reaction. While advent effective non-copper catalysts (i.e., Ru, Ag, Ir) demonstrated catalysis AAC reaction, additional robust catalytic systems complementary copper catalyzed remain in high demand. Herein, Au nanopar...