A 36-year-old woman with symptomatic metronidazole-resistant trichomonal vaginitis for 10 years had a total of 22 courses of treatment with either metronidazole or tinidazole according to different schedules. The minimum trichomonicidal concentration of metronidazole for the strain of Trichomonas vaginalis isolated from the patient was 160 microgram/ml compared with 1.25-10 microgram/ml for oth...

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D2A21, a novel peptide antibiotic has in vitro activity against a wide spectrum of sexually transmitted diseases (STD). In this study we tested the hypothesis that intravaginal D2A21 would interfere with acquisition of Trichomonas vaginalis infection in a modified mouse model. T. vaginalis infections of estrogenized young mice pretreated with Lactobacillus vaginalis or Lactobacillus rhamnosus w...

OBJECTIVE Trichomonas vaginalis analyte-specific reagent is a highly sensitive assay for T vaginalis detection. We report how this diagnostic innovation influenced the sexually transmitted infection ordering practice patterns of 20 subacute-care clinicians. METHODS T vaginalis, Neisseria gonorrhoeae, and/or Chlamydia trachomatis screening data were audited on female swab submissions when only...

Trichomonas vaginalis is a sexually transmitted obligate extracellular parasite that colonizes the human urogenital tract. Despite being of critical importance to the parasite's survival relatively little is known about the mechanisms employed by T. vaginalis to establish an infection and thrive within its host. Several studies have focused on the interaction of the parasite with host cells and...

Pregnancy Trichomonas vaginalis is a common cause of vaginitis in both the pregnant and nonpregnant patient. This protozoan is usually susceptible to metronidazole, but there is reluctance to administer this antibiotic to pregnant patients. The presence of T. vaginalis usually indicates that the vaginal ecosystem has become unbalanced. The microflora tends to shift from a lactobacilli-dominant ...

Urine samples were collected from 248 men, 21 of whom were known contacts of women infected with Trichomonas vaginalis. This organism was cultured from only three of the 21 specimens from patients in the contact group. The cultural technique was shown to be capable of reliably detecting small numbers of organisms under practical conditions; it appears, therefore, that most male contacts shed re...

We compared the use of universal transport medium and eSwab transport medium held at room temperature or 37 degrees C to bedside inoculation and immediate incubation of culture media for the detection of Trichomonas vaginalis. There were no significant culturable differences in the sensitivity of either of the transport media to that of bedside inoculation.