In this study we are concerned with the non-exact two-stage two-dimensional guillotine cutting problem considering usable leftovers, in which stock plates remainders of the cutting patterns (non-used material or trim loss) can be used in the future, if they are large enough to fulfill future demands of items (ordered smaller plates). This cutting problem can be characterized as a residual bin-p...

In this study we are concerned with the non-exact two-stage two-dimensional guillotine cutting problem considering usable leftovers, in which stock plates remainders of the cutting patterns (non-used material or trim loss) can be used in the future, if they are large enough to fulfill future demands of items (ordered smaller plates). This cutting problem can be characterized as a residual bin-p...

Although the latest enterprise resource planning software provides efficient scheduling of production processes, they have less impact on material marking process, since they focus on the utilization of materials and machines with respect to time. The classical optimization procedures are found to be inefficient in finding the optimal material usage, when the real world complex problems become ...

The flight envelope can be viewed as a set within the state space of an aircraft. For various safety considerations an aircraft is required to remain within its prescribed flight envelope. The safe set is the largest controlled invariant set within the flight envelope. Thus, if an aircraft is to remain within its envelope it must stay within the safe set. When an aircraft is impaired, e.g., a j...

In this work, we present a global potential energy surface for the ground electronic state of the H4(+) based on ab initio calculations. The final fit is based on triatomics-in-molecules (TRIM) approximation and it includes extra four-body terms for the better description of some discrepancies found on the TRIM model. The TRIM method itself allows a very accurate description of the asymptotic r...

Recurrent viral pressure has acted on host-encoded antiviral genes during primate and mammalian evolution. This selective pressure has resulted in dramatic episodes of adaptation in host antiviral genes, often detected via positive selection. These evolutionary signatures of adaptation have the potential to highlight previously unrecognized antiviral genes (also called restriction factors). Alt...

The innate antiviral response is integral in protecting the host against virus infection. Many proteins regulate these signaling pathways including ubiquitin enzymes. The ubiquitin-activating (E1), -conjugating (E2), and -ligating (E3) enzymes work together to link ubiquitin, a small protein, onto other ubiquitin molecules or target proteins to mediate various effector functions. The tripartite...

The members of tripartite-motif containing (TRIM) protein participate in various cellular processes and play an important role in host antiviral function. TRIM proteins exert their antiviral activity either directly by degrading viral proteins through their E3 ligase activity, or indirectly by promoting host innate immunity. This study demonstrated for the first time that TRIM52 is a novel anti...

It is well established that inlet flow characteristics may affect the performance of fluid handling systems considerably. This work focuses on the local flow analysis of a severe service control valve with a continuous resistance trim (CRT) operating under multiphase flow conditions and the effect of the inlet flow characteristics on the dispersed phase distribution within the trim and the valv...