This article focuses on the physico-chemical investigation of the time evolution of self-assembled structures composed by oppositely charged surfactant monomers. The cationic components were represented by the well known cetyl-trimethyl-ammonium-bromide (CTAB) while the anionic monomers consisted of amphiphilic ribonucleotide derivatives, also called nucleo-lipids (NL). The latter were generate...

Biopyrrin is an oxidative metabolite of bilirubin. Biopyrrin is a tripyrrol moiety of bilirubin, including two regioisomers (biotripyrrin-a, 1,14,15,17tetrahydro-2,7,13-trimethyl-1,14-deoxy-3-vinyl-16Htripyrrin-8,12-dipropionic acid and biotripyrrin-b, 1,14,15,17-tetrahydro-3,7,13-trimethyl-1,14-deoxy2-vinyl-16H-tripyrrin-8,12-dipropionic acid: Fig. 1). For many years, bilirubin was regarded as...

Studies on the feeding deterrent activity of some natural, cyclic terpenes (myrcene, (+)-3-carene, (+)-limonene, (±)-camphene), synthetic alkenes (2-methyl-1-pentene, 2,4,4-trimethyl-1-pentene, 1-methylcyclohexene, 1-tetradecene) and their derivatives α-methylenelactones in choice and no-choice tests against Colorado potato beetle with potato, Solanum tuberosum L. leaf discs as consuming food w...

It has been shown previously that kynurenine hydrolase (L-kynurenine hydrolase, EC 3.7.1.3) is inhibited by the hydrazide Benserazide {R,, 4-4602, DL-serine 2-[(2,3,4trihydroxyphenyl)methyl] hydrazide), a compound that is used clinically in the treatment of Parkinson’s disease (Bender et al., 1977). Benserazide is a potent inhibitor of aromatic amino acid decarboxylase (L-aromatic amino acid ca...

A new reagent for the oxidative cleavage of DNA, (1,4,7-trimethyl-1, 4,7-triazacyclononane)iron(III) chloride was recently introduced. We have determined the utility of this reagent for detecting protein-DNA interactions within two types of complexes. Interestingly, we find that the rates of DNA cleavage by this reagent are differentially affected by the two classes of protein-DNA interactons s...

Diamondoids in crude oil are useful for assessing the maturity of oil in high maturation. However, they are very difficult to separate and accurately quantify by conventional geochemical methods due to their low abundance in oil. In this paper, we use comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry (GC×GC-TOFMS) to study the compounds in condensates from t...

Camptothecin (CPT) exhibits very strong antitumor effects by inhibiting the activity of DNA topoisomerase I, but its application is greatly limited due to its low solubility and the instability of the active lactone form. To overcome these shortcomings, in the present study, we prepared novel camptothecin nanocolloids based on N,N,N-trimethyl chitosan (CPT-TMC) to efficiently and safely adminis...

Pentacoordinated iridium(i) complexes of formula IrCl(SiNP)(tfbb) (1) and IrCl(HNP)2(tfbb) (2) (SiNP = SiMe2{N(4-C6H4CH3)PPh2}2; HNP = NH(4-C6H4CH3)PPh2) have been prepared and fully characterised. Both feature a distorted square pyramidal coordination polyhedron at the metal centre in the solid state and are fluxional in solution. Their reaction with trimethyl phosphite yields the derivatives ...

This is the Final Statement of Reasons for specific regulatory levels for 22 chemicals listed as known to the State to cause cancer or reproductive toxicity under the Safe Drinking Water and Toxic Enforcement Act of 1986 (hereinafter the Act or Proposition 65), popularly known as “Proposition 65.” On June 8, 2001, the Office of Environmental Health Hazard Assessment (OEHHA) issued a Notice of P...