The objective of this study was to improve the solubility of albendazole and optimize the preparation of an oral nanoparticle formulation, using β-cyclodextrin (βCD) and chitosan-tripolyphosphate (TPP) nanoparticles. The solubility of albendazole in buffers, surfactants, and various concentrations of acetic acid solution was investigated. To determine drug loading, the cytotoxic effects of the ...

the present study deals with the formulation and evaluation of chitosan nanoparticles containing donepezil hydrochloride for the targeted delivery to the brain. nanoparticles were prepared by ionic gelation method using sodium tripolyphos-phate (tpp) as a cross linking agent followed by sonication. nanoparticles were obtained in the average size ranging from 116.8 to 227.5 nm. particle morpholo...

A novel particulate delivery matrix based on ionically crosslinked casein (CAS) nanoparticles was developed for controlled release of the poorly soluble anticancer drug flutamide (FLT). Nanoparticles were fabricated via oil-in-water emulsification then stabilized by ionic crosslinking of the positively charged CAS molecules below their isoelectric point, with the polyanionic crosslinker sodium ...

The objective of the study was to establish a pink threshold and simulate the pink defect in cooked chicken breast meat with treatment combinations that would induce significant changes in the color of raw and cooked meat. The subjective pink threshold used in judging pink discoloration was established at a* = 3.8. Samples of three color groups (normal, lighter than normal, and darker than norm...

<p>Penelitian ini bertujuan untuk memodifikasi kitosan dan digunakan sebagai sensor ion logam Cu(II). Modifikasi dilakukan dengan penaut silang menggunakan tripolifosfat dibentuk menjadi membran. Membran yang dihasilkan dianalisis spektrofotometer UV-Vis, <em>Fourier Transform InfraRed </em>(FTIR), <em>Scanning Electron Microscope-Energy Dispersive X-Ray</em> (SEM-...

The high transfection efficiency of polyethylenimine (PEI) makes it an attractive potential nonviral genetic vector for gene delivery and therapy. However, the highly positive charge of PEI leads to cytotoxicity and limits its application. To reduce the cytotoxicity of PEI, we prepared anion-enriched nanoparticles that combined PEI with tripolyphosphate (TPP). We then characterized the PEI-TPP ...

The CS-TPP nanoparticles were synthesized and their efficiency for removal of arsenic (V) ions at the optimum conditions was investigated. obtained with mass ratio tripolyphosphate to chitosan 1: 2 pH = 5.0. experimental data adsorption As followed Freundlich isotherm maximum capacity 77 mg/g 6.0. All experiments performed room temperature (25 °C). crosslinking sodium led a decrease in crystall...