Sciatic nerve is susceptible to trauma and injuries. Animal models for sciatic nerve trauma are mostly in rodents, with limited information about injury-induced neuropathy in non-human primates. We constructed a model of sciatic nerve neuropathy (SNN) in the cynomolgus macaque monkey, Macaca fascicularis, with mild injury to, but without transection of, the sciatic nerve. Monkeys’ behavioral an...

objective: because of the necessity of more effective treatments for the nervous system injuries and considering the role of survivin in cellular proliferation and apoptotic cell death, we have monitored survivin gene expression changes during the course of regeneration in injured sciatic nerves and also l4-l6 segments of spinal cord. materials and methods: we used adult male nmri mice as a mo...

Several studies have demonstrated that L-carnitine exhibits neuroprotective effects on injured sciatic nerve of rats with diabetes mellitus. It is hypothesized that L-carnitine exhibits neuroprotective effects on injured sciatic nerve of rats. Rat sciatic nerve was crush injured by a forceps and exhibited degenerative changes. After intragastric administration of 50 and 100 mg/kg L-carnitine fo...

Acupuncture has been widely used for pain control. However, the mechanism of pain inhibition by acupuncture is still unclear and evaluation of the physiological effects of acupuncture is limited 1,2) . Many studies have indicated that objective physiological measurements are associated with the determination of the effects of acupuncture. Physiological changes of the acupuncture can be detected...

background neuropathy is one of the most complications of diabetes that may be associated with changes in the structure and function of the basement membranes in nerves. laminin is one of the most important components of basement membranes in sciatic nerve. objectives in this study, the protective effects of alpha lipoic acid (ala) as an antioxidant agent on blood glucose level, body weight and...

conclusions coq10 abolished neuropathic pain in cci rats. prevention of cell loss might be attributed to the analgesic effect of coq10. hence, it might be used as a therapeutic intervention for neuropathic pain. background oxidative stress contributes to neuropathic pain. coenzyme q10 (coq10) is used for the treatment of neurodegenerative diseases. however, there is no report regarding the ther...

a b s t r a c tintroduction: peripheral nerve injury is a common disorder and leads to permanent neurological defects. schwann cells have been shown to have nerve repair after being transplanted in peripheral nerve injury. the aim of this study was to determine the beneficial effect of allograft schwann cells on electrophysiological outcome after transection of the sciatic nerve in rats.methods...

abstract traumatic hip dislocations are common in high-energy motor vehicle accidents. we present a case of a 43-year old man who sustained posterior hip dislocation with posterior wall acetabular fracture and ipsilateral intertrochantric fracture following a motorcycle accident. urgent open reduction and internal fixation of the hip fracture-dislocation and fixation of intertrochantric fractur...

Troxerutin is a bioflavonoid, which can be used to treat venous disorders, thrombosis and cerebrovascular diseases. Recent studies have demonstrated that it may also be used to prevent edemas. However, it is not known whether troxerutin protects against the cardiomyopathic complications of diabetes. In the present study, a rat model of type 2 diabetes was used to investigate the potential for t...

objective: to assess the neuroprotective effects of local administration of 17- beta- estradiol on nerve regeneration. methods: sixty female wistar rats were overiectomized and divided into four experimental groups (n = 15), randomly: in autograft group a segment of sciatic nerve was transected and re-implanted reversely. in sham-surgery group sciatic nerve was exposed and manipulated. in trans...