There is a mobile equilibrium between the native and denatured forms of trypsin which depends on the concentrations of acid, alkali, and alcohol and on the temperature. The heat of denaturation in 0.01 N hydrochloric acid calculated from the effect of temperature on the equilibrium constant is -67,600 calories per mole.

The research included isolation and purification of Trypsin from serum patient with pancreatic cancer, estimation its molecular weight by using the two techniques gel filtration (using sephadex G-50) electrophoresis SDS). Therefore; it was noted that proteinous peak isolated ammonium sulfate solution is saturated (65%) had apparent (27000) Dalton. study (40) patients pancreas cancer their ages ...

Trypsin mediates a release of arachidonic acid with resultant increase in O2 consumption (a reflection of cyclo-oxygenase activity) by whole human platelets that is similar to thrombin's effect on these cells. The trypsin and thrombin effects can be differentiated in two ways: (1) at saturating concentrations the measured effects of trypsin greatly exceed those of thrombin; (2) EGTA [ethanediox...

In 1916, Douglas and Colebrook noted that blood coagulation was accelerated by the addition of trypsin. A year later, Heard reported that trypsin could actually coagulate oxalated blood, and ascribed the phenomenon to a hypothetical disturbance in the Ca and P content of the fibrinogen, induced by the enzyme. These two reports were apparently overlooked by workers in the field. In 1928, Waldsch...

The geometry of the binary and ternary complexes of two black-eyed pea inhibitors with trypsin and chymotrypsin has been established by distance measurements using the technique of singlet-singlet energy transfer. Triangulation of measured distances in the ternary double-headed complex of the trypsin-chymotrypsin inhibitor (BEPCI) with trypsin and chymotrypsin limits the possible structural mod...

The disulfide-bridged hendecapeptide (CWTKSIPPKPC) loop, derived from an amphibian skin peptide, is found to have strong trypsin inhibitory capability. This loop, called the trypsin inhibitory loop (TIL), appears to be the smallest serine protease inhibitor known. A series of synthetic peptides derived from this loop also exhibits trypsin inhibitory activity; some peptides even exhibit both ant...