Shedding of prions via faeces may be involved in the transmission of contagious prion diseases. Here, we fed hamsters 10mg of 263K scrapie brain homogenate and examined the faecal excretion of disease-associated prion protein (PrP(TSE)) during the course of infection. The intestinal fate of ingested PrP(TSE) was further investigated by monitoring the deposition of the protein in components of t...

Methods: The mixed turbo spin echo pulse (mixed-TSE) sequence was implemented with second order binomial water-selective spatial-spectral excitation pulses (1), hereafter SSE-mixed-TSE (Figure 1). Mixed-TSE is a four time point pulse sequence that incorporates the principles of differential T1and T2-weighting in a single acquisition. By substituting the standard spatially-selective excitation p...

Background Double inversion recovery (DIR) and triple inversion recovery (TIR) prepared Turbo-Spin-Echo (TSE) are the most commonly used sequences for black-blood T2weighted (T2W) cardiac magnetic resonance. For both, cardiac motion often leads to signal loss and image inhomogeneity, which can affect diagnosis. Signal loss artifacts are thought to be due to misalignment of the black-blood prepa...

“Towards Software Excellence” (TSE) is a web-based process assessment facility established by the UK’s National Computing Centre (NCC). TSE provides software developers with a simple and easy-to-use means of self-assessing the capability of their development processes. They can understand the “good practice” expected by TSE, compare their processes against TSE’s process model, identify their "s...

The expression of the prion protein (PrP) is essential for transmissible spongiform encephalopathy (TSE) or prion diseases to occur, but the underlying mechanism of infection remains unresolved. To address the hypothesis that glycosylation of host PrP is a major factor influencing TSE infection, we have inoculated gene-targeted transgenic mice that have restricted N-linked glycosylation of PrP ...

The agents responsible for transmissible spongiform encephalopathies (TSEs), or prion diseases, contain as a major component PrP(Sc), an abnormal conformer of the host glycoprotein PrP(C). TSE agents are distinguished by differences in phenotypic properties in the host, which nevertheless can contain PrP(Sc) with the same amino-acid sequence. If PrP alone carries information defining strain pro...

Transmissible spongiform encephalopathy (TSE) or prion diseases are fatal rare neurodegenerative disorders affecting man and animals and caused by a transmissible infectious agent. TSE diseases are characterized by spongiform brain lesions with neuronal loss and the abnormal deposition in the CNS, and to less extent in other tissues, of an insoluble and protease resistant form of the cellular p...

OBJECTIVE To determine if a combination of ferucarbotran-enhanced T2*weighted-gradient echo (T2*W-GRE) and T2-weighted turbo spin echo (T2W-TSE) images in gadolinium- and ferucarbotran-enhanced MRI has additive efficacy compared to each image alone for detecting small (< or = 2.0 cm) hepatocellular carcinoma (HCC) lesions in a group of cirrhotic patients and metastases in a group of non-cirrhot...

It remains unclear whether the GSTM1 genotype interacts with tobacco smoke exposure (TSE) in asthma development. This study aimed to investigate the interactions among GSTM1 genotype, gender, and prenatal TSE with regard to childhood asthma development. In a longitudinal birth cohort in Taiwan, 756 newborns completed a 6-year follow-up, and 591 children with DNA samples available for GSTM1 geno...